There are two types of cross-matches: Major cross-match: This is the most important cross-match, comparing donor erythrocytes to recipient serum (i.e. you are checking for preformed (acquired or naturally occurring) antibodies in recipient serum against donor erythrocytes. The crossmatch is the final step of pretransfusion testing as a routine procedure. A portion of donor blood is combined with patient plasma or serum and is checked for agglutination, which would signify incompatible blood.
Also known as: Major Crossmatch Tube Method.