Red blood cells with partial D antigen type as D-positive, but individuals often produce anti-D when stimulated by transfusion or pregnancy. Some partial D, similar to weak D, result from point mutations in RHD that cause single amino acid changes. Historically, weak D red blood cells were defined as having decreased D antigen levels that required the indirect antiglobulin test for detection. Weak D phenotype most commonly results from a single point mutation in the transmembrane domain of the RHD gene.

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