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Practo

Diagnostic Tests

Couple Karyotyping

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Couple Karyotyping

Also known as Couple Karyotyping Blood
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What is this test?

Couple Karyotyping test is performed on a sample of blood to measure the level of Chromosome Analysis in the blood.It is performed to confirm or detect APLA syndrome and also after the treatment or during the treatment of Chromosome Anomaly, Genetic Disorders and Recurrent Miscarriages. Chromosome analysis or karyotyping is a test that evaluates the number and structure of a person's chromosomes in order to detect abnormalities. Chromosomes are thread-like structures within each cell nucleus and contain the body's genetic blueprint. Each chromosome contains thousands of genes in specific locations. These genes are responsible for a person's inherited physical characteristics and they have a profound impact on growth, development, and function. Humans have 46 chromosomes, present as 23 pairs. Twenty-two pairs are found in both sexes (autosomes) and one pair (sex chromosomes) is present as either XY (in males) or XX (in females). Normally, all cells in the body that have a nucleus will contain a complete set of the same 46 chromosomes, except for the reproductive cells (eggs and sperm), which contain a half set of 23. This half set is the genetic contribution that will be passed on to a child. At conception, half sets from each parent combine to form a new set of 46 chromosomes in the developing fetus. Chromosomal abnormalities include both numerical and structural changes. For numerical changes, anything other than a complete set of 46 chromosomes represents a change in the amount of genetic material present and can cause health and development problems. For structural changes, the significance of the problems and their severity depends upon the chromosome that is altered. The type and degree of the problem may vary from person to person, even when the same chromosome abnormality is present. A chromosomal karyotyping examines a person's chromosomes to determine if the right number is present and to determine if each chromosome appears normal. It requires experience and expertise to perform properly and to interpret the results. While theoretically almost any cells could be used to perform testing, in practice it is usually performed on amniotic fluid to evaluate a fetus and on lymphocytes (a white blood cell) from a blood sample to test all other ages. Alternately, white blood cells may be obtained from bone marrow aspirations to look for changes in individuals suspected of having hematologic or lymphoid diseases (e.g., leukemia, lymphoma, myeloma, refractory anemia).

Test Preparation

No special preparation is needed for Couple Karyotyping. Inform your doctor if you are on any medications or have any underlying medical conditions or allergies before undergoing Couple Karyotyping. Your doctor depending on your condition will give specific instructions.

Understanding your test results

GenderAge groupsValue
UNISEXAll age groupsThe observations depend on the cause: Genetic causes/ Chromosomal Anomalies
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