CD58 expression on nonmalignant B cells at different stages of maturation in the bone marrow and compared it with that of blasts in adult and pediatric precursor B-cell acute lymphoblastic leukemia (B-ALL). The mean fluorescence intensity (MFI) of CD58 expression decreased significantly as nonmalignant B cells differentiated in the bone marrow from an early to a mature stage. Few nonneoplastic B cells at a mid or mature stage of development expressed CD58 MFI values comparable to those seen in leukemic cases. Early-stage nonneoplastic B-cell precursors expressed relatively higher CD58 levels, which frequently overlapped with the variable level of CD58 expression observed among leukemic blasts. As a group, however, the malignant precursor B-ALL cells showed significantly higher expression of CD58 than nonmalignant B-cell populations at any maturational stage. These findings support the potential usefulness of CD58 expression in the diagnosis and monitoring of precursor B-ALL, but only when blasts express high levels of CD58. LFA-3 (CD58) is a membrane protein found on nearly all human cells. The interaction between LFA-3 and CD2 is very weak in solution, but when these glycoproteins are present in different membranes, the multivalent action of the receptor/counter-receptor pair leads to effective cell
No special preparation is needed for Cd 58 Immunohistochemistry Blood. Inform your doctor if you are on any medications or have any underlying medical conditions or allergies before undergoing Cd 58 Immunohistochemistry Blood. Your doctor depending on your condition will give specific instructions.
|UNISEX||All age groups||Test is positive if the conditions listed are detected|