CD1a is a membrane surface glycoprotein that has good specificity for Langerhans cells and immature T cells. In normal skin, CD1a stains scattered Langerhans cells in the upper dermis and epidermis; reactivity in normal thymus gland is in the cortical thymocytes (immature T cells). This immunostain is useful in phenotyping acute lymphoblastic leukemia/lymphoma of T-cell lineage and in diagnosis of Langerhans cell histiocytosis. Powerful antigen presenting cells present in skin and epithelia, from interdigitating cells. Immunohistochemical studies for CD1a antigen have reported a reduction in epidermal Langerhans cells in graft versus host disease and the participation of CD1a antigen-positive dendritic cells in atherosclerotic lesion formation and asthmatic inflammation.
No special preparation is needed for CD 1A. Inform your doctor if you are on any medications or have any underlying medical conditions or allergies before undergoing CD 1A. Your doctor depending on your condition will give specific instructions.
|UNISEX||All age groups||Test is positive if the conditions listed are detected|