Allergy Aspergillus Fumigatus

Aspergillus fumigatus is a hyaline mold that may cause human disease, including pneumonia and hypersensitivity. The invasive disease is more common in immunocompromised patients. A species of imperfect fungi from which the antibiotic fumigatin is obtained. Its spores may cause respiratory infection in birds and mammals. Asp f 2 is also a major allergen, with sensitisation to this allergen occurring in more than 90% of A. fumigatus-sensitised individuals. Similar to Asp f 1, sensitisation may vary depending on the underlying disease: in a study of 25 patients with ABPA, 96% had IgE antibodies directed against Asp f 2, whereas none of the normal control subjects, or the subjects with allergic asthma who had positive results on the skin-prick test, had a reaction.