Adrenocorticotropic hormone (ACTH or corticotropin) is a 39 amino acid . Clinical manifestations of immediate hypersensitivity (allergic) diseases are caused by the release of proinflammatory mediators (histamine, leukotrienes, and prostaglandins) from immunoglobulin E (IgE)-sensitized effector cells (mast cells and basophils) when cell-bound IgE antibodies interact with allergen.polypeptide hormone synthesised from pre-opiomelanocortin (POMC). It is secreted from corticotropes in the anterior lobe of the pituitary gland in response to a corticotropin-releasing hormone. The allergens chosen for testing often depend upon the age of the patient, history of allergen exposure, season of the year, and clinical manifestations. In individuals predisposed to develop allergic disease(s), the sequence of sensitization and clinical manifestations proceed as follows: eczema and respiratory disease (rhinitis and bronchospasm) in infants and children less than 5 years due to food sensitivity (milk, egg, soy, and wheat proteins) followed by respiratory disease (rhinitis and asthma) in older children and adults due to sensitivity to inhalant allergens (dust mite, mold, and pollen inhalants).
No special preparation is needed for Allergy Acth Enzyme Assay. Inform your doctor if you are on any medications or have any underlying medical conditions or allergies before undergoing Allergy Acth Enzyme Assay. Your doctor depending on your condition will give specific instructions.
|UNISEX||All age groups||Increased IgE (>100kU/l) is seen if the person is allergic to the specific substance|