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Tri-Olmecule-40 Tablet

Manufactured byInstanz Life Sciences Pvt. Ltd.
ContainsHydrochlorothiazide (12.5 mg) + Amlodipine (5 mg) + Olmesartan (40 mg)
Description
Tri-Olmecule-40 Tablet is a combination of Hydrochlorothiazide, Amlodipine and Olmesartan. It is used in the treatment of high blood pressure. This medicine works by relaxing the heart muscles and blood vessels. It also increases the water and sodium excretion from the body. Thus, it promotes the smooth flow of blood throughout the body. Tri-Olmecule-40 Tablet has some side effects like swelling in your ankles or feet, headache, sleepiness, dizziness, cough, nausea, and upset stomach. This medicine may cause you to urinate more often as it works by removing extra water from your body. If any of these side effects do not resolve with time or get worse, consult your doctor immediately. Avoid taking this medicine if you are allergic to it. Tri-Olmecule-40 Tablet can be taken with or without food. The dose will be decided by your doctor depending on your health condition. Take this medicine at the same time every day to maintain a constant level in the blood. Avoid the discontinuation of this medicine without your doctor's consultation as it can cause your blood pressure to rise, thereby increasing the risk of heart attack and stroke (a condition that occurs due to reduced blood supply to the brain). Tri-Olmecule-40 Tablet should be used with caution if you have kidney or liver problems, or diabetes. Inform your doctor if you are taking any other medicine before starting the treatment. Tri-Olmecule-40 Tablet is not recommended for use in children below 18 years of age. Consult your doctor if you are pregnant, planning a pregnancy, or are breastfeeding.

Side effects

Major & minor side effects for Tri-Olmecule-40 Tablet

  • Dizziness
  • Headache
  • Fatigue
  • Nausea and Vomiting
  • Diarrhoea
  • Increased urination
  • Joint pain
  • Swelling of ankles or feet
  • Upset stomach

Uses of Tri-Olmecule-40 Tablet

What is it prescribed for?

  • Hypertension
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Concerns

Commonly asked questions

  • How long does it take for this medicine to take effect?
    The time taken for Tri-Olmecule-40 Tablet to start its action is not known.
  • How long do the effects of this medicine last?
    The effect of Tri-Olmecule-40 Tablet lasts for an average duration of 24 hours.
  • Is it safe to consume alcohol while taking this medicine?
    Avoid consumption of alcohol while you are taking Tri-Olmecule-40 Tablet as it may further lower your blood pressure and make you feel dizzy or lightheaded.
  • Is this a habit forming medicine?
    Tri-Olmecule-40 Tablet has no habit-forming tendency.
  • Can this medicine be taken during pregnancy?
    Tri-Olmecule-40 Tablet is not recommended for use during pregnancy as it may harm your foetus. Consult your doctor if you are pregnant.
  • Can this medicine be taken while breast-feeding?
    Tri-Olmecule-40 Tablet is not recommended for use while breastfeeding as it may pass into breastmilk. Hence, consult your doctor if you are breastfeeding.

Allergy

Avoid taking Tri-Olmecule-40 Tablet if you are allergic to it. Seek immediate medical attention if you notice any symptoms such as skin rash, itching/swelling of the face/tongue/throat, breathing difficulty, etc.

Aliskiren

Coadministration of Tri-Olmecule-40 Tablet and Aliskiren (a medicine used to reduce blood pressure) is not recommended if you have diabetes (high blood sugar levels) and/or moderate to severe kidney impairment as it may increase the risk of kidney damage.

Anuria

Anuria is a condition in which the kidneys are unable to produce urine. Tri-Olmecule-40 Tablet is not recommended for use if you have anuria as it may further damage your kidneys.

Moderate to severe liver impairment

Tri-Olmecule-40 Tablet should be used with caution if you have moderate to severe liver problems as it may further worsen your condition.

Severe kidney impairment

Tri-Olmecule-40 Tablet is not recommended for use if you have severe kidney problems as it may increase the risk of accumulation of this medicine in the body. It may also cause further kidney damage.
Warnings for special population

Pregnancy

Tri-Olmecule-40 Tablet is not recommended for use during pregnancy as it may harm your foetus. Consult your doctor if you are pregnant.

Breast-feeding

Tri-Olmecule-40 Tablet is not recommended for use while breastfeeding as it may pass into breastmilk. Hence, consult your doctor if you are breastfeeding.
General warnings

Systemic lupus erythematosus

Systemic lupus erythematosus is an autoimmune disorder in which the immune system attacks its own tissues, causing swelling and tissue damage. It can affect the joints, skin, brain, lungs, kidneys, and blood vessels. Tri-Olmecule-40 Tablet should be used with caution if you have systemic lupus erythematosus as it may worsen your condition.

Driving and operating machines

Tri-Olmecule-40 Tablet may cause dizziness and a decrease in blood pressure. Avoid performing activities that require high mental alertness like driving vehicles or operating machines if you experience such symptoms.

Use in athletes

Tri-Olmecule-40 Tablet is not recommended to be used by athletes as per the World Anti-Doping Agency (WADA).

Volume and electrolyte depletion

Tri-Olmecule-40 Tablet may alter the blood volume and electrolyte levels. This may cause dizziness, dry mouth, thirst, weakness, acid-base imbalance (abnormality in the human body to balance between acid and base), etc. Hence, your blood pressure and electrolyte levels will be periodically monitored by your doctor while you are taking this medication.

Use in children

Tri-Olmecule-40 Tablet is not recommended for use in children and adolescents below 18 years of age as the safety and efficacy data are not clinically established.

Hypotension

Tri-Olmecule-40 Tablet should be used with caution as it may cause symptomatic hypotension (low blood pressure), especially if you have volume depletion (excess loss of salt and fluid from the body due to severe diarrhoea, vomiting, burns and kidney problems leading to reduced fluid volume). Your doctor may correct this condition before initiating treatment with Tri-Olmecule-40 Tablet.

Aortic stenosis

Aortic stenosis is the narrowing of the valves of the heart that regulates the blood flow from the heart to the body. Tri-Olmecule-40 Tablet should be used with caution if you have aortic stenosis. This medicine affects the contraction of the heart and may worsen your condition.

Hyperkalaemia

Tri-Olmecule-40 Tablet should be used with caution as it may cause hyperkalaemia (high potassium levels in the blood). Your doctor may suggest a test to monitor the potassium levels regularly. Avoid potassium-rich foods (potatoes, bananas) and potassium supplements during treatment with this medicine.

Liver problems

Tri-Olmecule-40 Tablet is broken down in the liver. Hence, this medicine should be used with caution if you have liver problems as it may increase the risk of liver damage. Your doctor may suggest tests to monitor your liver functions and/or recommend dose adjustments based on your clinical condition.

Kidney problem

Tri-Olmecule-40 Tablet should be used with caution if you have kidney problems as this medicine may alter kidney functions. Your doctor may suggest tests to closely monitor your kidney function or adjust the dose based on your clinical condition.

Missed Dose

If you miss a dose of Tri-Olmecule-40 Tablet, take it as soon as you remember. If it is time for your next scheduled dose, then skip the missed dose. Do not double your dose to make up for the missed one.

Overdose

Never take more than the prescribed dose of Tri-Olmecule-40 Tablet. If you suspect that you might have taken an overdose of this medicine, seek immediate medical attention.
All drugs interact differently for person to person. You should check all the possible interactions with your doctor before starting any medicine.
Interaction with Alcohol

Description

N/A

Instructions

Avoid consumption of alcohol while you are taking Tri-Olmecule-40 Tablet as it may further lower your blood pressure and make you feel dizzy or lightheaded.
Interaction with Medicine

Dexamethasone

Insulin

Itraconazole

Rifampicin

Diclofenac

Disease interactions

Cardiogenic shock

Tri-Olmecule-40 Tablet is not recommended for use in case of cardiogenic shock (a life-threatening situation in which your heart suddenly stops pumping enough blood to the body) as it may worsen your condition.

Diabetes

Tri-Olmecule-40 Tablet should be used with caution if you have diabetes (high blood sugar levels) as this medicine may alter blood sugar levels.

Hyperuricaemia

Tri-Olmecule-40 Tablet should be used with caution if you have hyperuricaemia (increased uric acid levels in the blood). This medicine decreases uric acid excretion and may further increase the levels of uric acid in your blood.

Congestive heart failure

Tri-Olmecule-40 Tablet should be used with caution if you have congestive heart failure (a condition in which your heart is unable to pump a sufficient amount of blood) due to the increased risk of kidney damage and worsening of your condition. Consult your doctor before taking this medicine.
Food interactions
Consumption of grapefruit juice is not recommended during treatment with Tri-Olmecule-40 Tablet as grapefruit juice can increase the absorption of this medicine in your body. This could lead to excessive lowering of your blood pressure and increased risk of side effects.
Lab interactions
Information not available.
Take Tri-Olmecule-40 Tablet exactly as advised by your doctor. Try taking this medicine during the daytime to avoid frequent urination at night. Drink plenty of water to avoid dehydration. Do not break, chew or crush the tablet. Take Tri-Olmecule-40 Tablet around the same time every day so that it is easy to remember. Tri-Olmecule-40 Tablet may cause swelling in your ankles and feet, therefore, avoid sitting for long hours and try raising your legs on a low stool when you are sitting. Avoid driving vehicles or operating machines and rise up slowly from a sitting or lying position if you feel dizzy during treatment with Tri-Olmecule-40 Tablet. To get maximum benefits from the treatment, you should also adopt lifestyle changes like eating a low sodium and low-fat diet, exercising regularly, quitting smoking, etc. Avoid potassium-rich foods like bananas, broccoli, etc. while taking this medicine.
Miscelleneous

Can be taken with or without food, as advised by your doctor

To be taken as instructed by doctor

May cause sleepiness

How it works
Tri-Olmecule-40 Tablet is a combination of Hydrochlorothiazide, Amlodipine and Olmesartan. Hydrochlorothiazide increases the excretion of water and sodium through the urine. Amlodipine relaxes the heart muscles and the blood vessels. Olmesartan relaxes the blood vessels and promotes a smooth flow of blood.
Legal Status

Approved

Approved

Unknown

Approved

Classification

Category

Miscellaneous antihypertensive combinations

Schedule

Schedule H

Accessdata.fda.gov. 2021. [online] Available at: < [Accessed 4 October 2021].

https://www.accessdata.fda.gov/drugsatfda_docs/label/2012/200175s011lbl.pdf>

Medicines.org.uk. 2021. [online] Available at: < [Accessed 4 October 2021].

https://www.medicines.org.uk/emc/files/pil.4596.pdf?filename=PIL.4596.pdf>

Ebs.tga.gov.au. 2021. TGA eBS - Product and Consumer Medicine Information Licence. [online] Available at: < [Accessed 4 October 2021].

https://www.ebs.tga.gov.au/ebs/picmi/picmirepository.nsf/pdf?OpenAgent&id=CP-2020-PI-01357-1&d=20211004172310101>

Dailymed.nlm.nih.gov. 2021. DailyMed - OLMESARTAN MEDOXOMIL, AMLODIPINE AND HYDROCHLOROTHIAZIDE 20/5/12.5 MG- olmesartan medoxomil, amlodipine and hydrochlorothiazide tablet 20/5/12.5 mg tabletOLMESARTAN MEDOXOMIL, AMLODIPINE AND HYDROCHLOROTHIAZIDE 40/5/12.5 MG- olmesartan medoxomil, amlodipine and hydrochlorothiazide tablet 40/5/12.5 mg tabletOLMESARTAN MEDOXOMIL, AMLODIPINE AND HYDROCHLOROTHIAZIDE 40/5/25 MG- olmesartan medoxomil, amlodipine and hydrochlorothiazide tablet 40/5/25 mg tabletOLMESARTAN MEDOXOMIL, AMLODIPINE AND HYDROCHLOROTHIAZIDE 40/10/12.5 MG- olmesartan medoxomil, amlodipine and hydrochlorothiazide tablet 40/10/12.5 mg tabletOLMESARTAN MEDOXOMIL, AMLODIPINE AND HYDROCHLOROTHIAZIDE 40/10/25 MG- olmesartan medoxomil, amlodipine and hydrochlorothiazide tablet 40/10/25 mg tablet. [online] Available at: < [Accessed 4 October 2021].

https://dailymed.nlm.nih.gov/dailymed/drugInfo.cfm?setid=85b8f9c6-aa53-4aa1-85d6-19f823d0d252>
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Information on this page was last updated on 22 Oct 2021

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