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Trajenta Duo 2.5 mg/ 500 mg Tablet

Manufactured byBoehringer Ingelheim India Pvt. Ltd.
ContainsMetformin (500 mg) + Linagliptin (2.5 mg)
Description
Trajenta Duo 2.5 mg/ 500 mg Tablet is a combination of Metformin and Linagliptin. It is an anti-diabetic medicine used in the treatment of type 2 diabetes in adults. It works by improving your body's response to insulin (a hormone that helps to control blood sugar levels). It also decreases sugar production, thereby lowering your blood sugar levels. Trajenta Duo 2.5 mg/ 500 mg Tablet shows side effects like headache, change in taste, nausea, diarrhoea, stomach pain, etc. This medicine can occasionally cause low blood sugar levels, the symptoms being sweating, dizziness, shivering, feeling tired, etc. Always carry a sugar source (sweets or fruit juice) with you to counteract such effects. Also, eat your meals on time to avoid low blood sugar levels. Alcohol consumption should be avoided while taking this medicine, as it can lower your blood sugar levels too. Trajenta Duo 2.5 mg/ 500 mg Tablet is recommended to be taken with food to avoid stomach discomfort. Take it at the same time every day to maintain a constant level of this medicine in your body. Do not skip a dose or discontinue the treatment as it may cause an increase in your blood sugar levels. Trajenta Duo 2.5 mg/ 500 mg Tablet is not recommended for use if you are allergic to it. Trajenta Duo 2.5 mg/ 500 mg Tablet may interact with other medicines, so inform your doctor if you are taking any medicines and/or supplements. Inform your doctor if you have kidney or liver problems. Trajenta Duo 2.5 mg/ 500 mg Tablet is not recommended for use in children below 18 years of age. Consult your doctor if you are pregnant or are breastfeeding.

Side effects

Major & minor side effects for Trajenta Duo 2.5 mg/ 500 mg Tablet

  • Anxiety
  • Blurred vision
  • Confusion
  • Dizziness
  • Nausea
  • Slurred speech
  • Unusual tiredness or weakness
  • Diarrhoea
  • Heartburn
  • Sore throat
  • Low blood sugar levels

Uses of Trajenta Duo 2.5 mg/ 500 mg Tablet

What is it prescribed for?

  • Type II Diabetes Mellitus
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Concerns

Commonly asked questions

  • How long does it take for this medicine to take effect?
    The amount of time required for Trajenta Duo 2.5 mg/ 500 mg Tablet to show its action is not clinically established.
  • How long do the effects of this medicine last?
    The amount of time for which Trajenta Duo 2.5 mg/ 500 mg Tablet remains active in your body is not clinically established.
  • Is it safe to consume alcohol while taking this medicine?
    Avoid consumption of alcohol during treatment with Trajenta Duo 2.5 mg/ 500 mg Tablet due to the increased risk of undesired effects.
  • Is this a habit forming medicine?
    No habit-forming tendency has been reported for Trajenta Duo 2.5 mg/ 500 mg Tablet.
  • Can this medicine be taken during pregnancy?
    Trajenta Duo 2.5 mg/ 500 mg Tablet is not recommended for use during pregnancy unless necessary. If you are pregnant, consult your doctor before taking this medicine.
  • Can this medicine be taken while breast-feeding?
    Trajenta Duo 2.5 mg/ 500 mg Tablet may pass into breastmilk. Hence, it is not recommended for use while breastfeeding unless necessary. Consult your doctor before taking this medicine.

Allergy

Trajenta Duo 2.5 mg/ 500 mg Tablet is not recommended for use if you are allergic to it. Seek immediate medical attention if you notice any symptoms such as skin rash, itching/swelling (especially of the face/tongue/throat), severe dizziness, breathing difficulty, etc.

Severe kidney impairment

Trajenta Duo 2.5 mg/ 500 mg Tablet is filtered by the kidneys and removed from the body via urine. Hence, it is not recommended for use if you have severe kidney problems as it may further worsen your condition.

Metabolic Acidosis

Metabolic acidosis is a condition with too much acid in your blood. The symptoms include vomiting, confusion, weakness, increased heartbeat, etc. Trajenta Duo 2.5 mg/ 500 mg Tablet is not recommended for use if you have metabolic acidosis as it may worsen your condition.

Type 1 Diabetes mellitus

Type 1 diabetes is a condition in which little or no insulin (substance required to break down sugar) is produced in your body. Trajenta Duo 2.5 mg/ 500 mg Tablet may not be effective in controlling your blood sugar level if you have type 1 Diabetes mellitus, also known as insulin-dependent Diabetes mellitus. Insulin injections are required to treat such a condition.

Diabetic ketoacidosis

Diabetic ketoacidosis is high amounts of acid in your blood. Trajenta Duo 2.5 mg/ 500 mg Tablet is not recommended for use if you have diabetic ketoacidosis as it may worsen your condition.
Warnings for special population

Pregnancy

Trajenta Duo 2.5 mg/ 500 mg Tablet is not recommended for use during pregnancy unless necessary. If you are pregnant, consult your doctor before taking this medicine.

Breast-feeding

Trajenta Duo 2.5 mg/ 500 mg Tablet may pass into breastmilk. Hence, it is not recommended for use while breastfeeding unless necessary. Consult your doctor before taking this medicine.
General warnings

Skin disorders

Trajenta Duo 2.5 mg/ 500 mg Tablet may increase the risk of skin lesions (abnormal changes on the skin). Therefore, inform your doctor if you experience any skin rashes, blisters (fluid-filled bumps), or lesions.

Use in children

Trajenta Duo 2.5 mg/ 500 mg Tablet is not recommended for use in children below 18 years of age as the safety and efficacy data are not clinically established.

Stress

Trajenta Duo 2.5 mg/ 500 mg Tablet is not recommended for use if you are experiencing stressful conditions like fever, trauma, operations, accidents. Consult your doctor about continuing this medicine in such cases.

Liver Diseases

Trajenta Duo 2.5 mg/ 500 mg Tablet should be used with caution if you have liver problems as it may increase the risk of undesired effects.

Hypoglycaemia

Hypoglycaemia is a condition with decreased blood sugar levels. Trajenta Duo 2.5 mg/ 500 mg Tablet should be used with caution as it may cause hypoglycaemia in some cases. Hence, monitor your blood sugar levels regularly while taking this medicine.

Missed Dose

Take the missed dose of Trajenta Duo 2.5 mg/ 500 mg Tablet as soon as you remember. If it is time for your next dose, skip the missed dose. Do not double your dose to make up for the missed one.

Overdose

Never take more than the prescribed dose. Contact your doctor in case of an overdose of Trajenta Duo 2.5 mg/ 500 mg Tablet.
All drugs interact differently for person to person. You should check all the possible interactions with your doctor before starting any medicine.
Interaction with Alcohol

Description

N/A

Instructions

Avoid consumption of alcohol during treatment with Trajenta Duo 2.5 mg/ 500 mg Tablet due to the increased risk of undesired effects.
Interaction with Medicine

Aripiprazole

Clozapine

Gatifloxacin

Dexamethasone

Ramipril

Disease interactions

Pancreatitis

Pancreatitis is the swelling of the pancreas, a gland that produces chemical substances which help in digestion and regulation of blood sugar. Trajenta Duo 2.5 mg/ 500 mg Tablet may increase the risk of pancreatitis and should be used with caution if you have a history of acute pancreatitis. Consult your doctor before taking this medicine.

Lactic Acidosis

Trajenta Duo 2.5 mg/ 500 mg Tablet increases the risk of developing a condition called lactic acidosis (increased level of lactic acid in your blood), especially if you have kidney or heart problems. Therefore, your doctor will suggest tests to monitor your kidney and heart function during the treatment with this medicine.

Vitamin B12 deficiency

Trajenta Duo 2.5 mg/ 500 mg Tablet interferes with the absorption of Vitamin B12 in your body. Hence, this medicine should be used with caution if you have vitamin B12 deficiency. Inform your doctor if you are taking vitamin B12 supplements before starting the treatment with this medicine.

Heart failure

Heart failure is a condition in which your heart is unable to pump a sufficient amount of blood. Trajenta Duo 2.5 mg/ 500 mg Tablet should be used with caution if you have heart failure as it may further worsen your condition. Your doctor may suggest tests to monitor the functioning of your heart while you are taking this medicine.
Food interactions
Information not available.
Lab interactions
Information not available.
Take Trajenta Duo 2.5 mg/ 500 mg Tablet as instructed by your doctor. Do not break, chew, or crush the tablet. Swallow as a whole with plenty of water. Your doctor may change the dose over time based on your therapeutic response and clinical condition. Avoid the discontinuation of Trajenta Duo 2.5 mg/ 500 mg Tablet without consulting your doctor, as it may cause an increase in blood sugar levels. It may also increase the risk of other diabetes-related complications. Always carry a sugar candy with you to counteract unexpected lowering of blood sugar levels. Monitor your blood sugar levels regularly. Maintain a strict diet regimen and exercise regularly for better results.
Miscelleneous

To be taken with food

To be taken as instructed by doctor

May cause sleepiness

How it works
Trajenta Duo 2.5 mg/ 500 mg Tablet is a combination of Metformin and Linagliptin. Metformin works by improving the body’s response to insulin (a chemical substance that helps regulate blood sugar levels) and decreasing sugar production in the liver. Linagliptin works by increasing the release of insulin from the pancreas (a gland that produces chemical substances which help in digestion and regulation of blood sugar). It also increases the activity of a hormone (Glucagon-like peptide-1), which helps to control blood sugar levels.
Legal Status

Approved

Approved

Unknown

Unknown

Classification

Category

Antidiabetic combinations

Schedule

Schedule H

Drugs, H., 2021. Metformin: MedlinePlus Drug Information. [online] Medlineplus.gov. Available at: < [Accessed 26 July 2021].

https://medlineplus.gov/druginfo/meds/a696005.html>

Pubchem.ncbi.nlm.nih.gov. 2021. Metformin. [online] Available at: < [Accessed 8 June 2021].

https://pubchem.ncbi.nlm.nih.gov/compound/4091#section=Top>

Docs.boehringer-ingelheim.com. 2022. [online] Available at: < [Accessed 3 February 2022].

https://docs.boehringer-ingelheim.com/Prescribing%20Information/PIs/Jentadueto/Patient%20Info/MedicationGuide.pdf>

Medicines.org.uk. 2022. [online] Available at: < [Accessed 4 February 2022].

https://www.medicines.org.uk/emc/files/pil.4762.pdf>

Drugs, H., 2022. Linagliptin: MedlinePlus Drug Information. [online] Medlineplus.gov. Available at: < [Accessed 4 February 2022].

https://medlineplus.gov/druginfo/meds/a611036.html>
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Information on this page was last updated on 14 Feb 2022

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