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Topnid 500 MG Injection

Manufactured byWinsome Lab Ltd.
Description
Topnid 500 MG Injection contains a hormone (chemical messenger) obtained from plants sources that mimic the action of the female hormone progesterone. This medicine is used for hormone replacement therapy and for the treatment of female infertility. Topnid 500 MG Injection is also used to treat cases of irregular periods. Topnid 500 MG Injection also helps to maintain healthy pregnancy by helping the uterus (womb) grow and preventing contractions during pregnancy. Topnid 500 MG Injection may be associated with certain side effects like nausea, headache, vomiting, upset stomach, constipation, pain at the injection site, etc. Inform your doctor if any of these side effects persist for a long time. Topnid 500 MG Injection is given by a qualified medical practitioner, therefore do not self administer it. Your doctor will determine the appropriate dose and duration of the therapy. This can vary depending on the condition you are being treated for and may change over time. Complete the course of this medicine and do not abruptly stop the treatment. Inform your doctor if you have any medical conditions like breast cancer, liver, kidney or heart problems. You may be advised few tests before and during the treatment with this medicine. Inform your doctor if you are breastfeeding to understand its benefits and risk to your baby.

Side effects

Major & minor side effects for Topnid 500 MG Injection

  • Headache
  • Mood swings
  • Vaginal discharge
  • Breast pain and tenderness
  • Muscle or joint pain
  • Constipation
  • Sneezing
  • Depression
  • Breast lumps
  • Loss of vision or blurred vision
  • Unexpected vaginal bleeding
  • Swelling of face, lips, eyelids, tongue, hands and feet
  • Nausea or Vomiting
  • Hot flashes

Uses of Topnid 500 MG Injection

What is it prescribed for?

  • Abnormal uterine bleeding
  • Amenorrhoea
  • Female infertility
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Concerns

Commonly asked questions

  • How long does it take for this medicine to take effect?
    The time Topnid 500 MG Injection takes to show its effect may vary from person to person. It also differs based on the indication it is used for and levels of other sex hormones in your body.
  • How long do the effects of this medicine last?
    The duration for which Topnid 500 MG Injection stays effective in your body varies depending on the intended usage and dosage administered. It may remain effective for 6-12 days depending on the dose.
  • Is it safe to consume alcohol while taking this medicine?
    Interaction with alcohol is unknown. It is advisable to consult your doctor before consumption.
  • Is this a habit forming medicine?
    No habit forming tendencies were reported for Topnid 500 MG Injection.
  • Can this medicine be taken during pregnancy?
    Topnid 500 MG Injection is safe to use during pregnancy. However, consult your doctor before taking this medicine.
  • Can this medicine be taken while breast-feeding?
    Topnid 500 MG Injection can pass through your milk, and the effect of this medicine on infants is not known. Hence it is advised to inform your doctor if you are breastfeeding.

Allergy

Topnid 500 MG Injection is not recommended for use if you have a known allergy to progesterone or other progestin analogues (synthetic hormones that act in a similar way as progesterone), or any other inactive ingredients of this medicine. Seek immediate medical attention if you notice any symptoms of serious allergic reactions such as skin rash, itching/swelling (especially of the face/tongue/throat), severe dizziness, breathing difficulty, etc.

Abnormal vaginal bleeding

Topnid 500 MG Injection is not recommended for use if you have an abnormal vaginal bleeding episode that has not been diagnosed by a doctor. If you have any menstrual abnormalities, report them to the doctor immediately.

Miscarriage

Avoid using Topnid 500 MG Injection if you had a miscarriage/ missed abortion (foetus is not alive and present inside the uterus) recently, as it may cause serious side effects and worsen your health condition.

Heart and blood vessel disorder

Avoid using Topnid 500 MG Injection if you have a history of stroke (brain damage due to blocked blood flow), heart attack or any medical condition that causes blood clotting problems. Using this medicine increases the risk of blood coagulation which may worsen your condition. Inform your doctor about your medical history before taking this medicine.

Liver disease

Topnid 500 MG Injection is absorbed in the liver and improper liver function can lead to its accumulation. Avoid this medicine if you have severe liver problems. If you notice any signs of jaundice (like yellowish discolouration of skin and eyes) or other liver-related problems, discontinue the use of this medicine and inform your doctor.

Breast cancer

If you have or suspect having breast cancer, do not take Topnid 500 MG Injection as it may worsen your condition. Before taking this medicine, inform your doctor if you have a family history of breast cancer. Your doctor will monitor your clinical condition during the treatment with this medicine. It is also not recommended for use if you have or suspect hormone-related cancers [such as the cancer of the uterus (womb) or other sex organs].
Warnings for special population

Pregnancy

Topnid 500 MG Injection is safe to use during pregnancy. However, consult your doctor before taking this medicine.

Breast-feeding

Topnid 500 MG Injection can pass through your milk, and the effect of this medicine on infants is not known. Hence it is advised to inform your doctor if you are breastfeeding.
General warnings

Dizziness and drowsiness

Topnid 500 MG Injection may cause dizziness or drowsiness, hence do not drive or operate heavy machines if you experience any of these symptoms. Consult with your doctor if these symptoms persist.

Vision abnormalities

Topnid 500 MG Injection may cause vision problems like blurred or double vision, or loss of vision. Inform your doctor immediately if you experience these vision problems, also do not drive or operate heavy machines.

Other medicines

It is recommended to report the use of all your current medicines including supplements and herbs to the doctor before receiving Topnid 500 MG Injection.

Peanut allergy

Topnid 500 MG Injection may contain peanut oil in it. Hence avoid its use if you have a known allergy to peanuts.

Missed Dose

Since Topnid 500 MG Injection is usually administered by a qualified healthcare professional in the clinical/hospital setting, the likelihood of a missed dose is very low. However, if an injection schedule is missed, inform your doctor immediately. Your doctor will give you further instructions about the changed dosing schedule.

Overdose

Since Topnid 500 MG Injection is usually administered under the supervision of a qualified healthcare professional, the likelihood of an overdose is very low. However, emergency medical treatment will be provided if your doctor suspects an overdose of this medicine.
All drugs interact differently for person to person. You should check all the possible interactions with your doctor before starting any medicine.
Interaction with Alcohol

Description

Interaction with alcohol is unknown. It is advisable to consult your doctor before consumption.

Instructions

Interaction with alcohol is unknown. It is advisable to consult your doctor before consumption.
Interaction with Medicine

Carbamazepine

Ketoconazole

Insulin

Phenobarbital

Disease interactions

Thromboembolism

Thromboembolism is a condition in which a blood clot is dislodged from another location in the circulation and causes obstruction in the blood flow. Topnid 500 MG Injection when used in high doses can cause blood clot formation and may worsen your condition.

Depression

Depression is a mood disorder that causes feelings of sadness, loss, anger and loss of interest in all activities. Topnid 500 MG Injection should be used with caution if you are diagnosed with depression or other mental health conditions as it may cause hallucinations, aggressiveness, mood swings, suicidal thoughts and other behavioural changes.

Retinal thrombosis

Retinal thrombosis is an eye condition that occurs as a result of blood clot formation in the vein in the retina (part of the eye that enables vision). It is a painless condition that causes blurring or loss of eyesight. It usually always occurs in only one eye. Use Topnid 500 MG Injection with caution if you have renal thrombosis as it may cause side effects such as loss of vision, blurred vision, or retinal vascular lesions. This risk is especially high if you have a history of vision problems or have active vision problems.

Fluid Retention and Oedema

Topnid 500 MG Injection can cause fluid retention and oedema (swelling of the tissues beneath your skin) especially when used for a long period. Use it with caution if you have a history of excess fluid retention.

Hyperlipidaemia

Topnid 500 MG Injection should be used with extreme caution if you are diagnosed with hyperlipidaemia (increased fat levels in the blood) as it may increase the fat deposits and worsen your condition.
Food interactions
Information not available.
Lab interactions

Blood coagulation tests

Report the use of Topnid 500 MG Injection to the doctor before undergoing a test to measure the coagulation (blood clot) time. The use of this medicine may interfere with the test results.

Thyroid function tests

Topnid 500 MG Injection is known to give a false-positive result for thyroid function tests. Hence inform the lab technician or doctor about its use.
Topnid 500 MG Injection is administered in a proper healthcare setting by specialized healthcare professionals. Do not self administer. Inform your doctor if you have a known allergy to this medicine. Before getting this medicine, inform your doctor about all of your current medications as well as any health condition you are having.
Miscelleneous

Usage does not depend on food timings

To be taken as instructed by doctor

May cause sleepiness

How it works
Topnid 500 MG Injection infertility by regulating menstrual periods in women with secondary amenorrhoea (absence of a menstrual period for three or more months). This medicine maintains pregnancy by preparing the uterine (womb) lining to accommodate a fertilised egg (which develops into a baby).
Legal Status

Approved

Approved

Unknown

Unknown

Classification

Category

Progestins, Hormones

Schedule

Schedule H

Progesterone [Internet]. Pubchem.ncbi.nlm.nih.gov. 2020 [cited 7 February 2020]. Available from:

https://pubchem.ncbi.nlm.nih.gov/compound/Progesterone

[Internet]. Accessdata.fda.gov. 2020 [cited 10 February 2020]. Available from:

https://www.accessdata.fda.gov/drugsatfda_docs/label/2007/017362s104lbl.pdf

Medicines.org.uk. 2021. Utrogestan 100mg Capsules - Summary of Product Characteristics (SmPC) - (emc). [online] Available at: < [Accessed 29 July 2021].

https://www.medicines.org.uk/emc/product/352/smpc>

Drugs, H., 2021. Progesterone: MedlinePlus Drug Information. [online] Medlineplus.gov. Available at: < [Accessed 29 July 2021].

https://medlineplus.gov/druginfo/meds/a604017.html>

Hormone.org. 2021. Progesterone. [online] Available at: < [Accessed 29 July 2021].

https://www.hormone.org/your-health-and-hormones/glands-and-hormones-a-to-z/hormones/progesterone>

Dailymed.nlm.nih.gov. 2021. DailyMed - PROGESTERONE injection. [online] Available at: < [Accessed 29 July 2021].

https://dailymed.nlm.nih.gov/dailymed/drugInfo.cfm?setid=83cfc12e-75d1-4284-bcc3-beadcbd27171>
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Information on this page was last updated on 18 Nov 2021

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We’ve made all possible efforts to ensure that the information provided here is accurate, up-to-date and complete, however, it should not be treated as a substitute for professional medical advice, diagnosis or treatment. Practo only provides reference source for common information on medicines and does not guarantee its accuracy or exhaustiveness. The absence of a warning for any drug or combination thereof, should not be assumed to indicate that the drug or combination is safe, effective, or appropriate for any given patient. Practo does not assume any responsibility for any aspect of healthcare administered with the aid of information provided above. If you have any doubts about your medication then we strongly recommend that you consult with your doctor, nurse or healthcare provider. See detailed T&C here.