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Tobracef 1.120 g Injection

Manufactured byVENUS REMEDIES LTD
ContainsCeftazidime (1000 mg) + Tobramycin (120 mg)
Description

Tobracef 1.120 g Injection is a combination medicine used for the treatment of lower respiratory tract infections caused by Pseudomonas aeruginosa. It may also be used for the treatment of serious central nervous system infections, intra-abdominal infections, skin and skin structure infections, etc. caused by susceptible strains of bacteria.

Side effects

Major & minor side effects for Tobracef 1.120 g Injection

  • Abdominal pain
  • Bloating
  • Diarrhea
  • Swelling and redness at the injection site
  • White patches in the mouth or on the tongue
  • Dizziness
  • Fast heartbeat
  • Headache
  • Skin rash
  • Yellow colored eyes or skin
  • Neuromuscular blockade
  • Hearing loss
  • Ringing or buzzing in the ears
  • Nosebleed
  • Difficulty in breathing
  • Hoarseness of voice
  • Unusual tiredness and weakness
  • Fever

Uses of Tobracef 1.120 g Injection

What is it prescribed for?

  • Lower Respiratory Tract Infection
  • Serious bacterial infections
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Concerns

Commonly asked questions

  • How long does it take for this medicine to take effect?
    The effect of this medicine occurs rapidly after an intravenous administration.
  • How long do the effects of this medicine last?
    The effect of this medicine lasts for an average duration of 12 to 24 hours.
  • Is it safe to consume alcohol while taking this medicine?
    Interaction with alcohol is unknown. It is advisable to consult your doctor before consumption.
  • Is this a habit forming medicine?
    No habit-forming tendencies were reported.
  • Can this medicine be taken during pregnancy?
    This medicine is not recommended for use in pregnant women unless absolutely necessary. All the risks and benefits should be discussed with the doctor before receiving this medicine.
  • Can this medicine be taken while breast-feeding?
    This medicine is not recommended for use in breastfeeding women unless absolutely necessary. All the risks and benefits should be discussed with the doctor before receiving this medicine.

Allergy

This medicine is not recommended for use in patients with a known allergy to ceftazidime, any other beta-lactam antibiotics, tobramycin, any other aminoglycosides, or any other inactive ingredients present along with these medicines.
Warnings for special population

Pregnancy

This medicine is not recommended for use in pregnant women unless absolutely necessary. All the risks and benefits should be discussed with the doctor before receiving this medicine.

Breast-feeding

This medicine is not recommended for use in breastfeeding women unless absolutely necessary. All the risks and benefits should be discussed with the doctor before receiving this medicine.
General warnings

Drug-resistance

Usage of this medicine without sufficient proof or suspicion of a bacterial infection should be avoided. Irrational dosing might fail in providing the benefits and even cause toxicity. It may also increase the risk of development of bacteria that are drug-resistant.

Clostridium difficile-associated Diarrhea

Discontinue the use of this medicine as per the doctor's instructions if severe diarrhea occurs after receiving this medicine. This medicine may cause an imbalance in the microbial flora of the large intestine, decreasing the gut-friendly bacteria and promoting the growth of a bacteria called Clostridium difficile, resulting in severe diarrhea.

Neurotoxicity

This medicine may increase the risk of serious adverse effects such as encephalopathy, seizures, and nonconvulsive status epilepticus. These reactions may occur in patients with an impaired kidney function if the dose of this medicine is not adjusted appropriately. Appropriate dose adjustments or replacement with a suitable alternative may be required based on the clinical condition of the patient.

Neuromuscular disorders

This medicine is not recommended for use in patients with a history of neuromuscular disorders such as parkinsonism or myasthenia gravis due to the increased risk of worsening of the patient's condition.

Dehydration

Patients are advised to consume an adequate amount of fluids to prevent dehydration during treatment with this medicine. Fluid status should be monitored closely, especially for patients suffering from vomiting or diarrhea. Close monitoring of kidney function tests and electrolytes levels, appropriate corrective measures, dose adjustments, or replacement with a suitable alternative may be required based on the clinical condition of the patient.

Missed Dose

Since this medicine is administered by a qualified healthcare professional in the clinical or hospital setting, the likelihood of a missed dose is very low.

Overdose

Since this medicine is administered in the hospital or clinical setting by a qualified healthcare professional, the likelihood of an overdose is very low. However, emergency medical treatment will be initiated by the doctor if an overdose is suspected.
All drugs interact differently for person to person. You should check all the possible interactions with your doctor before starting any medicine.
Interaction with Alcohol

Description

Interaction with alcohol is unknown. It is advisable to consult your doctor before consumption.

Instructions

Interaction with alcohol is unknown. It is advisable to consult your doctor before consumption.
Interaction with Medicine

Amikacin

Colistin

Ethinyl Estradiol

Cholera Vaccine

Cyclosporine

Diuretics

Neuromuscular blockers

Disease interactions

Renal Dysfunction

This medicine should be used with extreme caution in patients with renal diseases due to the increased risk of serious adverse effects. Close monitoring of kidney function is necessary while receiving this medicine. Appropriate dose adjustments or replacement with a suitable alternative may be required based on the clinical condition of the patient.

Gastrointestinal Disorders

This medicine should be used with extreme caution in patients having a history of gastrointestinal diseases, particularly colitis, since it may worsen the patient's condition. Report any incidence of severe diarrhea, abdominal pain, blood in stools, etc. to the doctor immediately. Appropriate dose adjustments or replacement with a suitable alternative may be required based on the clinical condition of the patient.

Seizure disorders

This medicine should be used with extreme caution in patients with a history of seizure disorder and other central nervous system abnormalities since it may worsen the patient's condition. Report any incidence of tremors, restlessness, anxiety, confusion, hallucinations, etc., to the doctor on priority. Appropriate dose adjustments or replacement with a suitable alternative may be necessary based on the clinical condition of the patient.

Liver Disease

This medicine should be used with caution in patients with liver diseases due to the increased risk of serious adverse effects. Close monitoring of liver function is necessary while receiving this medicine. Appropriate dose adjustments or replacement with a suitable alternative may be necessary based on the clinical condition of the patient.
Food interactions
Information not available.
Lab interactions
Information not available.
This medicine should be administered by a qualified healthcare professional in the clinical or hospital setting. Inform the doctor if you have a known allergy to this medicine. Report to the doctor all your current medicines including herbs and supplements as well as all your medical conditions before receiving this medicine. Report any undesired side effects to the doctor on priority.
Miscelleneous

Usage does not depend on food timings

To be taken as instructed by doctor

May cause sleepiness

How it works
This medicine works by stopping the growth of bacteria.
Legal Status

Approved

Unknown

Unknown

Unknown

Classification

Category

Third generation cephalosporins, Aminoglycosides

Schedule

Schedule H

[Internet]. Accessdata.fda.gov. 2018 [cited 15 March 2018]. Available from:

https://www.accessdata.fda.gov/drugsatfda_docs/label/2017/050578s061,050634s028lbl.pdf

[Internet]. Lothianrespiratorymcn.scot.nhs.uk. 2018 [cited 15 March 2018]. Available from:

http://www.lothianrespiratorymcn.scot.nhs.uk/wp-content/uploads/2010/11/Antibiotic_guideline_final__20111.pdf

DailyMed - Tobramycin injection, powder, lyophilized, for solution [Internet]. Dailymed.nlm.nih.gov. 2017 [cited 21 July 2017]. Available from:

https://dailymed.nlm.nih.gov/dailymed/drugInfo.cfm?setid=a384641c-04e3-4ab5-b152-7408cd07b64d&audience=consumer

[Internet]. Venusremedies.com. 2018 [cited 31 May 2018]. Available from:

http://www.venusremedies.com/tobracef
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Information on this page was last updated on 31 May 2018

Disclaimer

We’ve made all possible efforts to ensure that the information provided here is accurate, up-to-date and complete, however, it should not be treated as a substitute for professional medical advice, diagnosis or treatment. Practo only provides reference source for common information on medicines and does not guarantee its accuracy or exhaustiveness. The absence of a warning for any drug or combination thereof, should not be assumed to indicate that the drug or combination is safe, effective, or appropriate for any given patient. Practo does not assume any responsibility for any aspect of healthcare administered with the aid of information provided above. If you have any doubts about your medication then we strongly recommend that you consult with your doctor, nurse or healthcare provider. See detailed T&C here.