Tinzaparin
Description
Tinzaparin is an anticoagulant used along with warfarin to prevent the formation and growth of blood clots in patients with certain specific medical conditions. It is also used to prevent blood clots that may potentially form during certain medical procedures.
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Side effects
Major & minor side effects for Tinzaparin
- Injection site redness, bruising, or sores
- Dizziness
- Change in heart rate
- Chest pain and discomfort
- Sleeplessness
- Reduced blood cell count
- Difficulty in breathing
- Redness of skin
- Difficulty with passing urine
- Headache
- Nausea or vomiting
- Constipation or diarrhea
- Back pain
Uses of Tinzaparin
What is it prescribed for?
- Deep Vein Thrombosis
- Venous thromboembolic events
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Concerns
Commonly asked questions
- Onset of actionThe effect of this medicine can be observed within 2-3 hours of administration.
- Duration of effectThe effect of this medicine lasts for an average duration of 12-14 hours.
- Safe with alcohol?Interaction with alcohol is unknown. It is advisable to consult your doctor before consumption.
- Is it habit forming?No habit forming tendencies were reported.
- Usage in pregnancy?This medicine is recommended for use in pregnant women only when absolutely necessary and the potential benefits outweigh the risks involved.
- Usage while breast-feeding?This medicine is not recommended for use in breastfeeding women since the safety and efficacy of use are not clinically established. Your doctor may decide the best course of treatment after assessing your condition.
Allergy
This medicine is not recommended for use in patients with a known allergy to tinzaparin or any other inactive ingredient present along with it. Use of this medicine is also not recommended in patients having a known allergy to heparin or pork products.
Active major bleeding
This medicine is not recommended for use in patients with a known heavy active bleeding due to the increased risk of worsening of the patient's condition.
Thrombocytopenia
This medicine is not recommended for use in patients with an abnormally low platelet count due to the increased risk of excessive bleeding.
Hemorrhagic cardiovascular events
This medicine is not recommended for use in patients who are at an increased risk of internal bleeding or hemorrhages due to the risk of worsening of the patient's condition.
Severe kidney damage
This medicine is not recommended for use in patients with a severe impairment of kidney function due to the increased risk of death. This risk is especially higher in the elderly patients. Appropriate dose adjustments or replacement with a suitable alternative may be necessary based on the clinical condition.
Warnings for special population
Pregnancy
This medicine is recommended for use in pregnant women only when absolutely necessary and the potential benefits outweigh the risks involved.
Breast-feeding
This medicine is not recommended for use in breastfeeding women since the safety and efficacy of use are not clinically established. Your doctor may decide the best course of treatment after assessing your condition.
General warnings
Hemorrhage and risk factors
Use of this medicine should be initiated only after internal bleeding or hemorrhage and associated risk factors are ruled out. All the underlying causes of bleeding such as peptic ulcer disease, hemophilia, impaired hemostasis, etc. should also be ruled out before the administration of this medicine.
Thrombocytopenia
Use of this medicine may cause low levels of platelets (thrombocytopenia). It is advised to monitor the blood platelet levels at regular intervals while this medicine is administered. Appropriate dose adjustments or replacement with a suitable alternative may be necessary based on the clinical condition of the patient.
Benzyl alcohol as preservative
Dosage forms containing benzyl alcohol as a preservative should not be administered to neonates, infants, pregnant or breastfeeding women. Benzyl alcohol may cause a fatal adverse event known as Gasping syndrome in neonates and infants.
Liver/kidney disease
This medicine should be used with caution in patients having an impairment of normal liver/kidney function. Appropriate dose adjustments and frequent clinical monitoring are recommended for such patients. Replacement with a suitable alternative may be necessary based on the clinical condition.
Other medicines
This medicine may interact with many other medicines and may cause severe side effects. Hence, you are advised to report the use of all medicines including herbs and supplements to the doctor before beginning treatment with this medicine.
Epidural/spinal/regional anesthesia
This medicine should not be used in patients receiving regional, epidural, or spinal anesthesia due to the increased risk of excessive bleeding and formation of hematoma.
Interchangeability with other heparins
This medicine should not be used interchangeably with other low molecular weight heparins.
Use in elderly
This medicine should be used with extreme caution in the elderly patients since the risk of adverse effects is significantly high.
Priapism
Use of this medicine has been associated with priapism in some rare cases. Any unusual symptoms should be reported to the doctor on priority. Therapy with this medicine may need to be discontinued based on the clinical condition.
Hyperkalaemia
This medicine should be used with extreme caution in patients who are at an increased risk of hyperkalemia. Close monitoring of potassium levels is advised for such patients. Appropriate dose adjustments or replacement with a suitable alternative may be necessary based on the clinical condition of the patient.
Missed Dose
This medicine is usually administered in a clinical or hospital setup. However, if you are administering it at home and miss a scheduled dose, then call your doctor immediately for further instructions.
Overdose
Seek emergency medical attention in case of an overdose or suspected overdose. Symptoms may include nosebleed, unusual bruising and bleeding, and the presence of blood in stool or urine.
All drugs interact differently for person to person. You should check all the possible interactions with your doctor before starting any medicine.
Interaction with Alcohol
Description
Interaction with alcohol is unknown. It is advisable to consult your doctor before consumption.
Instructions
Interaction with alcohol is unknown. It is advisable to consult your doctor before consumption.
Interaction with Medicine
Clopidogrel
Lisinopril
Warfarin
Aspirin
Apixaban
Diclofenac
Streptokinase
Ubiquinone/Vitamin E
Activated Protein C
Disease interactions
Peptic ulcer disease
This medicine should be administered with extreme caution in patients with peptic ulcer disease due to the increased risk of excessive bleeding.
Bacterial endocarditis
This medicine should be used with extreme caution in patients with subacute bacterial endocarditis, characterized by swelling of the heart walls or valves due to a bacterial infection, due to the risk of worsening of the patient's condition.
Kidney Disease
This medicine should be administered with extreme caution in patients suffering from kidney diseases due to the increased risk of worsening of the patient's condition. Appropriate dose adjustments or replacement with a suitable alternative may be necessary based on the clinical condition of the patient.
Hemophilia
This medicine should be administered with extreme caution in patients suffering from hemophilia or other bleeding disorders due to the increased risk of excessive bleeding.
Uncontrolled hypertension
This medicine is not recommended for use in patients having an uncontrolled high blood pressure. Therapy with this medicine should be started only after the hypertension is under control.
Food interactions
This medicine should be used with caution with fish oil or other food products containing omega-3 polyunsaturated fatty acids due to the increased risk of bleeding. Contact your doctor immediately if you experience any unusual bleeding or bruising, dizziness, weakness, and presence of blood in sputum/urine/stool. Your doctor/dietitian may suggest appropriate changes in your diet to avoid this interaction.
This medicine should be used with caution with ginger/garlic due to the increased risk of bleeding. Contact your doctor immediately if you experience any unusual bleeding or bruising, dizziness, weakness, and the presence of blood in sputum/urine/stool. Your doctor/dietitian may suggest appropriate changes in your diet to avoid this interaction.
Lab interactions
Information not available.
Administer Tinzaparin exactly as instructed by the doctor. It should not be injected into the muscles. It is advised to administer this medicine under the supervision of a doctor in a clinical setup with regular monitoring of blood clotting time and other related parameters. Your doctor may ask you to undergo certain tests to determine the safety of use of this medicine.
Miscelleneous
How it works
This medicine works by interfering with the normal clotting process and decreasing the clot forming ability of the blood.
Legal Status
Classification
Category
Heparins
Schedule
Schedule H
[Internet]. 2017 [cited 31 August 2017]. Available from:
[Internet]. 2017 [cited 31 August 2017]. Available from:
[Internet]. 2017 [cited 31 August 2017]. Available from:
DailyMed - INNOHEP- tinzaparin sodium injection [Internet]. Dailymed.nlm.nih.gov. 2017 [cited 31 August 2017]. Available from:
Tinzaparin - DrugBank [Internet]. Drugbank.ca. 2017 [cited 31 August 2017]. Available from:
Information on this page was last updated on 4 Sep 2017
Disclaimer
We’ve made all possible efforts to ensure that the information provided here is accurate, up-to-date and complete, however, it should not be treated as a substitute for professional medical advice, diagnosis or treatment. Practo only provides reference source for common information on medicines and does not guarantee its accuracy or exhaustiveness. The absence of a warning for any drug or combination thereof, should not be assumed to indicate that the drug or combination is safe, effective, or appropriate for any given patient. Practo does not assume any responsibility for any aspect of healthcare administered with the aid of information provided above. If you have any doubts about your medication then we strongly recommend that you consult with your doctor, nurse or healthcare provider. See detailed T&C here.