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Safeguard (75 mg/200 mcg) Tablet
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Safeguard (75 mg/200 mcg) Tablet

Manufactured byPulse Pharmaceuticals Pvt. Ltd.
ContainsDiclofenac (75 mg) + Misoprostol (200 mcg)
Description
Safeguard (75 mg/200 mcg) Tablet is a combination medicine used to treat the pain and swelling associated with Osteoarthritis and Rheumatoid arthritis. It is not recommended for use in children under 18 years of age.
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Side effectsConcernsUsageRelated products

Side effects

Major & minor side effects for Safeguard (75 mg/200 mcg) Tablet

  • Constipation
  • Vomiting
  • Rash
  • Itching
  • Diarrhea
  • Headache
  • Dizziness
  • Difficulty in falling asleep
  • Stomach ache
  • Nausea

Uses of Safeguard (75 mg/200 mcg) Tablet

What is it prescribed for?

  • Rheumatoid Arthritis
  • Osteoarthritis
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Concerns

Commonly asked questions

  • How long does it take for this medicine to take effect?
    The amount of time required for this medicine to show its action is not clinically established.
  • How long do the effects of this medicine last?
    The amount of time for which this medicine remains active in the body is not clinically established.
  • Is it safe to consume alcohol while taking this medicine?
    Consumption of alcohol is not recommended during treatment with this medicine due to the increased risk of serious side effects such as severe gastrointestinal bleeding, dizziness, fatigue, weakness, etc.
  • Is this a habit forming medicine?
    No habit forming tendency has been reported.
  • Can this medicine be taken during pregnancy?
    This medicine is not recommended for use in pregnant women.
  • Can this medicine be taken while breast-feeding?
    This medicine is not recommended for use in breastfeeding women.

Allergy

This medicine is not recommended for use in patients with a known allergy to diclofenac, other NSAIDs, misoprostol, or any other prostaglandin medicines.

Ulcer or Perforation

This medicine is not recommended for use in patients with an active ulcer or perforation in the stomach or intestines.

Coronary Artery Bypass Surgery (CABG)

This medicine is not recommended for relieving pain before, during, or after a coronary artery bypass graft (CABG) procedure.

Pregnancy

This medicine is not recommended for use in pregnant women due to the increased risk of fetal harm.
Warnings for special population

Pregnancy

This medicine is not recommended for use in pregnant women.

Breast-feeding

This medicine is not recommended for use in breastfeeding women.
General warnings

Advanced Renal disease

This medicine is not recommended for use in patients with a known history of advanced renal disease due to the increased risk of worsening of the patient's condition.

Inflammation of intestine

This medicine should be used with caution in patients with a known history of ulcerative colitis or Crohn's disease due to the increased risk of worsening of the patient's condition. Replacement with a suitable alternative may be required based on the clinical condition.

Liver impairment

This medicine should be used with caution in patients with a known history of liver diseases due to the increased risk of severe adverse effects. Appropriate dose adjustments or replacement with a suitable alternative may be required based on the clinical condition.

Dehydration

This medicine should be used with caution in patients with dehydration due to the increased risk of worsening of the patient's condition. Appropriate dose adjustments should be considered based on the clinical condition.

Excessive bleeding

This medicine may cause excessive bleeding in some patients. Report any symptoms such as blood in the stool or vomit, weakness, fatigue, dizziness, etc. to the doctor on priority. Replacement with a suitable alternative should be considered based on the clinical condition.

Elderly patients

This medicine should be used with caution in elderly patients due to the increased risk of severe adverse effects. Appropriate dose adjustments or replacement with a suitable alternative may be required in some cases based on the clinical condition.

Driving or operating machines

This medicine may cause dizziness or drowsiness in some patients. It is advised that you do not perform any activities that require high mental alertness like driving a vehicle or operating machinery if you experience these symptoms during treatment with this medicine.

Women of childbearing potential

Women of childbearing potential should use effective contraceptive measures to avoid pregnancy during treatment with this medicine. A pregnancy test should be done to rule out pregnancy before beginning treatment. If pregnancy is suspected during treatment, therapy should be discontinued and an alternative treatment option should be considered.

Missed Dose

Take the missed dose as soon as you remember. If it is almost time for your next dose, skip the missed dose. Do not double your dose to make up for the missed one.

Overdose

Seek emergency medical treatment or contact the doctor in case of an overdose.
All drugs interact differently for person to person. You should check all the possible interactions with your doctor before starting any medicine.
Interaction with Alcohol

Description

N/A

Instructions

Consumption of alcohol is not recommended during treatment with this medicine due to the increased risk of serious side effects such as severe gastrointestinal bleeding, dizziness, fatigue, weakness, etc.
Interaction with Medicine

Methotrexate

Ramipril

Adefovir

Apixaban

Ketorolac

Dinoprostone

Antacids containing magnesium

Disease interactions

Asthma

This medicine is not recommended for use in patients with a known history of NSAID-sensitive asthma. Replacement with a suitable alternative should be done under your doctor's supervision.

Fluid retention and Edema

This medicine may cause fluid retention and edema in some patients. Close monitoring of blood pressure, electrolyte levels, and heart function may be required based on the clinical condition. Appropriate dose adjustments or replacement with a suitable alternative may be necessary in some cases.

Gastro-Intestinal toxicity

This medicine may cause damage to the stomach, intestines, liver, etc., especially on prolonged use. Report any symptoms such as chronic indigestion, blood in stool or vomit, etc. to the doctor immediately. Appropriate dose adjustments or replacement with a suitable alternative may be required based on the clinical condition.

Skin rash

This medicine may cause fatal skin allergies without any warnings in some patients. Signs and symptoms such as rashes, hives, fever, or other allergic symptoms should be reported to the doctor without any delay. Appropriate corrective measures, dose adjustments, or replacement with a suitable alternative may be required based on the clinical condition.

Impaired kidney function

This medicine should be used with caution in patients with a history of kidney diseases due to the increased risk of severe adverse effects. Close monitoring of the renal function is necessary while receiving this medicine. Appropriate dose adjustments or replacement with a suitable alternative may be required in some cases based on the clinical condition.

Heart attack and stroke

This medicine may cause a heart attack, stroke, or other associated symptoms after a prolonged use. This risk is especially higher in patients with a history of heart diseases. Close monitoring of heart function is recommended for such patients. Report any symptoms such as a chest pain, shallow breathing, speech slurring, weakness, etc. to the doctor immediately. Appropriate dose adjustments or replacement with a suitable alternative may be required based on the clinical condition.
Food interactions
Information not available.
Lab interactions
Information not available.
This is not an exhaustive list of possible drug interactions. You should consult your doctor about all the possible interactions of the drugs you’re taking.
Take Safeguard (75 mg/200 mcg) Tablet with food or immediately after a meal. Do not take in larger amounts than prescribed. Consult the doctor if you experience any undesirable side effects. Ensure that the treatment course is completed. Do not stop the use of this medicine without consulting your doctor.
Miscelleneous

To be taken with food

To be taken as instructed by doctor

May cause sleepiness

How it works
Diclofenac works by reducing the formation of certain substances in the body that cause pain and swelling. Misoprostol is a prostaglandin analog which reduces gastric acid secretion and protects the walls of the stomach. The combination thus becomes effective by reducing the frequency of stomach ulcers caused by Diclofenac.
Legal Status

Approved

Approved

Approved

Approved

Classification

Category

Nonsteroidal anti-inflammatory agents

Schedule

Schedule H

DailyMed - Diclofenac Sodium and Misoprostol tablet, delayed release [Internet]. Dailymed.nlm.nih.gov. 2017 [cited 13 September 2017]. Available from:

https://dailymed.nlm.nih.gov/dailymed/drugInfo.cfm?setid=df8b8660-0c24-4848-8bea-c1b935090c66

Diclofenac and Misoprostol: MedlinePlus Drug Information [Internet]. Medlineplus.gov. 2017 [cited 13 September 2017]. Available from:

https://medlineplus.gov/druginfo/meds/a699002.html

EMC [Internet]. 2017 [cited 13 September 2017]. Available from:

https://www.medicines.org.uk/emc/medicine/1898

EMC [Internet]. 2017 [cited 13 September 2017]. Available from:

https://www.medicines.org.uk/emcmobile/PIL.4144.latest.pdf

[Internet]. EAGLEUS. 2017 [cited 13 September 2017]. Available from:

http://www.eagleus.com/wp-content/uploads/2015/08/diclofenac-misoprostol-package-insert.pdf

PFIZER [Internet]. 2017 [cited 13 September 2017]. Available from:

http://www.pfizer.ca/sites/g/files/g10017036/f/201505/Arthrotec_PM_06JJan2015_E.pdf

FDA [Internet]. 2017 [cited 13 September 2017]. Available from:

https://www.accessdata.fda.gov/drugsatfda_docs/label/2009/020607s014lbl.pdf
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Information on this page was last updated on 24 Sep 2017

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