Piozone G (15/2 mg) Tablet

Manufactured byAbbott Healthcare Pvt. Ltd.
ContainsGlimepiride (2 mg) + Pioglitazone (15 mg)
Description

Piozone G (15/2 mg) Tablet is a combination medicine used to control high blood glucose levels in patients with type 2 diabetes mellitus. Patients are advised to maintain a strict exercise and diet regimen along with this medicine to get the best possible effect.

Substitutes

List of substitutes for Piozone G (15/2 mg) Tablet

Side effects

Major & minor side effects for Piozone G (15/2 mg) Tablet

  • Hypoglycemia
  • Bloody and cloudy urine
  • Painful urination
  • Swelling of face, lips, eyelids, tongue, hands and feet
  • Difficult and painful breathing
  • Irregular heartbeat
  • Weight gain
  • Upper respiratory tract infection
  • Headache
  • Fracture of bones
  • Severe muscle pain
  • Disorder of teeth
  • Dizziness
  • Asthenia
  • Flu like symptoms
  • Allergic skin reaction
  • Elevated liver enzymes

Uses of Piozone G (15/2 mg) Tablet

What is it prescribed for?

  • Type II Diabetes Mellitus
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Concerns

Commonly asked questions

  • Onset of action
    The effect of this medicine can be observed within 1 hour of administration of the dose.
  • Duration of effect
    The amount of time for which this medicine remains active in the body is not clinically established.
  • Safe with alcohol?
    Consumption of alcohol is not recommended during treatment with this medicine due to the increased risk of severe adverse effects.
  • Is it habit forming?
    No habit forming tendency has been reported.
  • Usage in pregnancy?
    This medicine is not recommended for use in pregnant women unless absolutely necessary. All the risks and benefits should be discussed with the doctor before taking this medicine. Your doctor may prescribe a safer alternative based on your clinical condition.
  • Usage while breast-feeding?
    This medicine is not recommended for use in breastfeeding women unless absolutely necessary. All the risks and benefits should be discussed with the doctor before taking this medicine. Your doctor may advise you to discontinue breastfeeding or to discontinue the drug based on your clinical condition.

Allergy

This medicine is not recommended for use in patients with a known allergy to pioglitazone, glimepiride, other sulphonamide derivatives, or any other inactive ingredients present along with these medicines.

Heart Failure

This medicine is not recommended for use in patients suffering from a moderate to severe heart failure since it may worsen the patient's condition.

Active liver disease

This medicine is not recommended for use in patients with an active liver disease or ALT levels greater than 2.5 times the upper limit of normal since it may worsen the patient's condition.

Bladder cancer

This medicine is not recommended for use in patients with bladder cancer since it may worsen the patient's condition.
Warnings for special population

Pregnancy

This medicine is not recommended for use in pregnant women unless absolutely necessary. All the risks and benefits should be discussed with the doctor before taking this medicine. Your doctor may prescribe a safer alternative based on your clinical condition.

Breast-feeding

This medicine is not recommended for use in breastfeeding women unless absolutely necessary. All the risks and benefits should be discussed with the doctor before taking this medicine. Your doctor may advise you to discontinue breastfeeding or to discontinue the drug based on your clinical condition.
General warnings

Type I diabetes mellitus

This medicine is not recommended for use in patients suffering from Type I diabetes since it is not effective in treating such patients.

Cardiovascular diseases

This medicine should be used with extreme caution in patients with a known history of cardiovascular diseases due to the increased risk of worsening of the patient's condition. Report any unusual symptoms to the doctor immediately. Close monitoring of heart function, appropriate dose adjustments, or replacement with a suitable alternative may be required based on the clinical condition.

Liver diseases

This medicine should be used with caution in patients with a known history of liver disease due to the increased risk of worsening of the patient's condition. Appropriate dose adjustments or replacement with a suitable alternative may be required based on the clinical condition.

Edema

This medicine should be used with caution in patients with edema due to the increased risk of worsening of the patient's condition.

Ovulation

This medicine should be used with caution due to the increased chances of ovulation in premenopausal anovulatory women. Adequate contraceptive measures are recommended for such patients to avoid an unplanned pregnancy.

Fractures

This medicine may increase the risk of fractures in some patients. This risk is especially higher in female patients. Close monitoring of bone health is recommended during treatment with this medicine. Replacement with a suitable alternative may be required based on the clinical condition.

Pediatric use

This medicine is not recommended for use in children and adolescents.

Antidiabetic agents

This medicine should be used with caution in patients taking other antidiabetic agents due to the increased risk of very low blood glucose levels. Close monitoring of blood glucose levels and appropriate dose adjustments may be required based on the clinical condition.

Hypoglycemia

This medicine may cause hypoglycemia in some patients. This risk is especially higher in patients suffering from kidney diseases, malnourishment, pituitary gland diseases, etc. Close monitoring of blood glucose levels is recommended for such patients. Appropriate dose adjustments may be required based on the clinical condition. Your doctor may advise you to carry a sugar candy to counteract the effects of low blood sugar levels (hypoglycemia).

Stress

Use of this medicine should be discontinued in patients exposed to stressful conditions such as a fever, trauma, surgeries, or accidents since it may not be effective in controlling blood sugar levels in these conditions. Replacement with a suitable alternative should be considered under your doctor's supervision.

Kidney disease

This medicine should be used with caution in patients with a known history of kidney disease due to the increased risk of worsening of the patient's condition. Appropriate dose adjustments or replacement with a suitable alternative may be required based on the clinical condition.

Photo-sensitivity

This medicine may cause allergic skin reactions on exposure to sunlight in some patients. Patients are advised to use sunscreen and wear protective clothing to avoid these reactions. Replacement with a suitable alternative may be required if the reactions are severe.

Change of medications

You may experience some temporary side effects if there is a change in the current medications used for diabetes mellitus. This overlapping effect is because of the change from one medicine to another. Close monitoring of blood sugar levels is recommended in these cases.

Missed Dose

Take the missed dose as soon as you remember. If it is almost time for your next dose, skip the missed dose. Do not double your dose to make up for the missed one.

Overdose

Seek emergency medical treatment or contact the doctor in case of an overdose.
All drugs interact differently for person to person. You should check all the possible interactions with your doctor before starting any medicine.
Interaction with Alcohol

Description

N/A

Instructions

Consumption of alcohol is not recommended during treatment with this medicine due to the increased risk of severe adverse effects.
Interaction with Medicine

Diclofenac

Fluconazole

Gatifloxacin

Ketoconazole

Miconazole

Rifampicin

Colesevelam

Gemfibrozil

Aloe Vera

Insulin injection

Disease interactions

Congestive heart failure

This medicine is not recommended for use in patients with a known history of congestive heart failure due to the increased risk of fluid retention and worsening of the heart failure.

Bladder cancer

Use of this medicine is not recommended in patients having an active bladder tumor since it may worsen the patient's condition.

Liver Disease

This medicine should be used with extreme caution in patients with a known history of liver impairment due to the increased risk of adverse effects. Close monitoring of liver function, appropriate dose adjustments, or replacement with a suitable alternative may be required based on the clinical condition.

Anemia

This medicine is not recommended for use in patients suffering from anemia since it may worsen the patient's condition. Appropriate dose adjustments or replacement with a suitable alternative may be required based on the clinical condition.

Kidney disease

This medicine should be used with extreme caution in patients with a known history of kidney impairment due to the increased risk of adverse effects. Close monitoring of kidney function, appropriate dose adjustments, or replacement with a suitable alternative may be required based on the clinical condition.

Hypoglycemia

This medicine should be administered with caution in patients prone to having low blood glucose level episodes. Close monitoring of blood glucose levels is recommended for such patients. Appropriate dose adjustments or replacement with a suitable alternative may be required based on the clinical condition.
Food interactions
Information not available.
Lab interactions
Information not available.
Take this medicine as instructed by your doctor. It is advised to take this medicine with meals. Your dose is likely to change over time based on therapeutic response and clinical condition. Regular monitoring of blood sugar levels is recommended during treatment with this medicine. You should always carry a sugar candy with you to counteract unexpected lowering of blood sugar levels. Do not change the dose or duration of use without consulting your doctor. This medicine will show better results if you maintain a strict exercise and diet regimen. Consult the doctor if you experience any undesirable side effects.
Miscelleneous

To be taken with food

To be taken as instructed by doctor

Does not cause sleepiness

How it works
Glimepiride increases the secretion of insulin from the pancreas and also regulates the release of glucose from the liver. Pioglitazone decreases insulin resistance without causing any strain on the pancreas and reduces the production of glucose from the liver.
Legal Status

Approved

Unknown

Unknown

Unknown

Classification

Category

Antidiabetic combinations

Schedule

Schedule H

DailyMed - Pioglitazone hydrochloride tablet [Internet]. Dailymed.nlm.nih.gov. 2017 [cited 16 March 2017]. Available from:

https://dailymed.nlm.nih.gov/dailymed/drugInfo.cfm?setid=8f2d7000-37ca-4e09-98ec-07d1c0354cb3

Pioglitazone | C19H20N2O3S - PubChem [Internet]. Pubchem.ncbi.nlm.nih.gov. 2017 [cited 16 March 2017]. Available from:

https://pubchem.ncbi.nlm.nih.gov/compound/4829

DailyMed - Glimepiride tablet [Internet]. Dailymed.nlm.nih.gov. 2017 [cited 24 February 2017]. Available from:

https://dailymed.nlm.nih.gov/dailymed/drugInfo.cfm?setid=60e9397e-83b9-489e-9683-6f87e458bbaa

[Internet]. 2017 [cited 24 February 2017]. Available from:

https://www.accessdata.fda.gov/drugsatfda_docs/label/2009/020496s021lbl.pdf
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