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Penalgon MR (400/8 mg) Tablet
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Penalgon MR (400/8 mg) Tablet

Manufactured byEmenox Healthcare
ContainsEtodolac (400 mg) + Thiocolchicoside (8 mg)
Description
Penalgon MR (400/8 mg) Tablet is a combination medicine used in the treatment of pain, swelling, and inflammation in conditions such as osteoarthritis, rheumatoid arthritis, acute muscle spasms, low back pain, etc.
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Side effectsConcernsUsage

Side effects

Major & minor side effects for Penalgon MR (400/8 mg) Tablet

  • Itching and skin rash
  • Swelling of face, lips, eyelids, tongue, hands and feet
  • Fainting and drowsiness
  • Nausea and Vomiting
  • Diarrhea
  • Yellowing of skin and eyes
  • Photosensitivity
  • Dry mouth
  • Headache
  • Stomach pain
  • Blurred vision
  • Fever or chills
  • Excessive gas in stomach
  • Ringing or buzzing in the ears
  • Sneezing

Uses of Penalgon MR (400/8 mg) Tablet

What is it prescribed for?

  • Muscle spasm with acute pain
  • Osteoarthritis
  • Rheumatoid Arthritis
  • Mild to Moderate pain
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Concerns

Commonly asked questions

  • How long does it take for this medicine to take effect?
    The amount of time required for this medicine to show its action is not clinically established.
  • How long do the effects of this medicine last?
    The amount of time for which this medicine remains active in the body is not clinically established.
  • Is it safe to consume alcohol while taking this medicine?
    Consumption of alcohol is not recommended while receiving this medicine due to the increased risk of gastrointestinal bleeding. Report any symptoms of bleeding such as coughing up blood or blood in the stools to the doctor immediately. Appropriate corrective measures or replacement with a suitable alternative may be required based on the clinical condition.
  • Is this a habit forming medicine?
    No habit forming tendency has been reported.
  • Can this medicine be taken during pregnancy?
    This medicine is not recommended for use in pregnant women due to the increased risk of fetal harm. Your doctor may prescribe a safer alternative based on the clinical condition.
  • Can this medicine be taken while breast-feeding?
    This medicine is not recommended for use in breastfeeding women due to the increased risk of severe adverse effects in the nursing infant. Your doctor may prescribe a safer alternative based on the clinical condition.

Allergy

This medicine is not recommended for use in patients with a known allergy to etodolac, any other NSAIDs, thiocolchicoside, or any other inactive ingredient present along with these medicines.

Asthma

This medicine is not recommended for use in patients with asthma caused by aspirin or other non-steroidal anti-inflammatory drugs since it may worsen the patient's condition.

Gastrointestinal disorders

This medicine is not recommended for use in patients with gastrointestinal bleeding disorders or active peptic ulcers since it may worsen the patient's condition.

Heart surgery

This medicine is not recommended for use in relieving pain before or after a heart surgery due to the increased risk of severe adverse effects.
Warnings for special population

Pregnancy

This medicine is not recommended for use in pregnant women due to the increased risk of fetal harm. Your doctor may prescribe a safer alternative based on the clinical condition.

Breast-feeding

This medicine is not recommended for use in breastfeeding women due to the increased risk of severe adverse effects in the nursing infant. Your doctor may prescribe a safer alternative based on the clinical condition.
General warnings

Other medicines

Report the use of all your current medicines including herbs and supplements to the doctor to avoid the chances of a possible interaction with this medicine.

Drowsiness

Use of this medicine may cause drowsiness, impaired judgment, and impaired normal body movements. Hence, it is advised that you do not perform any activities that require high mental alertness such as driving a vehicle or operating heavy machinery during treatment with this medicine.

Use in children

This medicine is not recommended for use in children and adolescents.

Use in women of childbearing potential

Women of childbearing potential should adopt appropriate means of contraception to avoid pregnancies during treatment with this medicine. A pregnancy test should be done to rule out pregnancy before beginning treatment. If pregnancy is suspected during treatment, therapy should be discontinued and an alternative treatment option should be considered.

Impairment of fertility

Use of this medicine may cause impairment of fertility in men. Discuss all the risks and benefits with your doctor before taking this medicine.

Skin rash

This medicine may cause serious skin allergies without any warnings. These events may be fatal in rare cases. Signs and symptoms like rashes, hives, fever, or other allergic symptoms should be reported to the doctor immediately. The treatment should be discontinued if these symptoms appear.

Elderly population

This medicine should be used with caution in elderly population due to an increase in the risk of undesired side effects. Close monitoring of kidney function and symptoms of bleeding is recommended for such patients. Appropriate dose adjustments may be required based on the clinical condition.

Missed Dose

The missed dose can be taken as soon as you remember it. If it is almost time for your next scheduled dose, skip the missed dose. Do not double the dose to make up for the missed one.

Overdose

Seek emergency medical treatment or contact the doctor in case of an overdose.
All drugs interact differently for person to person. You should check all the possible interactions with your doctor before starting any medicine.
Interaction with Alcohol

Description

N/A

Instructions

Consumption of alcohol is not recommended while receiving this medicine due to the increased risk of gastrointestinal bleeding. Report any symptoms of bleeding such as coughing up blood or blood in the stools to the doctor immediately. Appropriate corrective measures or replacement with a suitable alternative may be required based on the clinical condition.
Interaction with Medicine

Ramipril

Warfarin

Ketorolac

Prednisolone

Disease interactions

Heart Disease

This medicine should be used with caution in patients with heart diseases due to the increase in the risk of fluid accumulation in the body. Inform the doctor if you have any heart diseases before receiving this medicine. The dose of the medicine may be reduced or an alternate treatment option may be considered based on the clinical condition.

Impaired kidney function

This medicine should be used with caution due to an increase in the risk of kidney injury. Close monitoring of kidney function is necessary while receiving this medicine. The dose of the medicine may be reduced or an alternate treatment option may be considered based on the clinical condition.

Impaired liver function

This medicine should be used with caution due to an increase in the risk of liver injury. Close monitoring of liver function is necessary while receiving this medicine. The dose of the medicine may be reduced or an alternate treatment option may be considered based on the clinical condition.
Food interactions
Information not available.
Lab interactions
Information not available.
This is not an exhaustive list of possible drug interactions. You should consult your doctor about all the possible interactions of the drugs you’re taking.
Take this medicine exactly as prescribed by the doctor. Do not take in larger or smaller quantities than recommended. Do not take this medicine for longer durations than recommended. Report any unusual symptoms to the doctor immediately. Do not stop the use of this medicine without consulting your doctor.
Miscelleneous

To be taken immediately after food

To be taken as instructed by doctor

May cause sleepiness

How it works
Etodolac works by preventing the formation of chemical substances in the body that cause pain and swelling. Thiocolchicoside works by interacting with certain specific receptors in the central nervous system to prevent muscle contractions and relieve muscle spasms.
Legal Status

Approved

Unknown

Unknown

Unknown

Classification

Category

Non-steroidal anti-inflammatory agents, Muscle relaxants

Schedule

Schedule H

[Internet]. 2017 [cited 20 September 2017]. Available from:

https://www.medicines.org.uk/emc/medicine/27532

Etodolac: MedlinePlus Drug Information [Internet]. Medlineplus.gov. 2017 [cited 20 September 2017]. Available from:

https://medlineplus.gov/druginfo/meds/a692015.html

DailyMed - Etodolac tablet, extended release [Internet]. Dailymed.nlm.nih.gov. 2017 [cited 20 September 2017]. Available from:

https://dailymed.nlm.nih.gov/dailymed/drugInfo.cfm?setid=107ea9d7-80a9-41a4-b61e-168370127319

[Internet]. 2017 [cited 20 September 2017]. Available from:

http://www.ema.europa.eu/docs/en_GB/document_library/Referrals_document/Thiocolchicoside-containing_medicines/WC500155449.pdf

Thiocolchicoside - DrugBank [Internet]. Drugbank.ca. 2017 [cited 20 September 2017]. Available from:

https://www.drugbank.ca/drugs/DB11582
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Information on this page was last updated on 28 Sep 2017

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