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Nexopil-D 40 Tablet
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Nexopil-D 40 Tablet

Manufactured byPSYCHOTROPICS INDIA LTD
ContainsEsomeprazole (40 mg) + Domperidone (20 mg)
Description
Nexopil-D 40 Tablet is a combination medicine which may be used in the treatment of gastroesophageal reflux disease (GERD) in patients who are not responding adequately to esomeprazole alone. It may also be used to treat gastric acid-related disorders. This medicine is not recommended for use in patients with moderate-to-severe liver function impairment.
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Side effectsConcernsUsage

Side effects

Major & minor side effects for Nexopil-D 40 Tablet

  • Swelling of face, lips, eyelids, tongue, hands and feet
  • Difficulty in breathing
  • Skin rash
  • Disrupted menstrual cycle
  • Breast pain and tenderness
  • Dry mouth
  • Diarrhea
  • Dizziness
  • Headache
  • Irregular heartbeat

Uses of Nexopil-D 40 Tablet

What is it prescribed for?

  • Gastroesophagal Reflux Disease
  • Gastric Acid Related Disorders
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Concerns

Commonly asked questions

  • How long does it take for this medicine to take effect?
    The effect of this medicine can be observed within 30 to 60 minutes of administration.
  • How long do the effects of this medicine last?
    The effect of this medicine lasts for an average duration of 16-18 hours.
  • Is it safe to consume alcohol while taking this medicine?
    Interaction with alcohol is unknown. It is advisable to consult your doctor before consumption.
  • Is this a habit forming medicine?
    No habit-forming tendencies were reported.
  • Can this medicine be taken during pregnancy?
    This medicine is not recommended for use in pregnant women unless necessary. All the risks and benefits should be discussed with the doctor before taking this medicine.
  • Can this medicine be taken while breast-feeding?
    This medicine is not recommended for use in breastfeeding women unless necessary. All the risks and benefits should be discussed with the doctor before taking this medicine.

Allergy

This medicine is not recommended for use in patients with a known allergy to domperidone, esomeprazole, other benzimidazoles, or any other inactive ingredients present in the formulation.

Tumor of Pituitary gland

This medicine is not recommended for use in patients with a tumor of the pituitary gland due to the increased risk of worsening the patient's condition.

Heart diseases

This medicine is not recommended for use in patients with heart diseases like congestive heart failure due to the increased risk of worsening the patient's condition.

Moderate to Severe Hepatic Impairment

This medicine is not recommended for use in patients with moderate to severe liver function impairment due to the increased risk of worsening the patient's condition.
Warnings for special population

Pregnancy

This medicine is not recommended for use in pregnant women unless necessary. All the risks and benefits should be discussed with the doctor before taking this medicine.

Breast-feeding

This medicine is not recommended for use in breastfeeding women unless necessary. All the risks and benefits should be discussed with the doctor before taking this medicine.
General warnings

Use in Children

This medicine is not recommended for use in patients less than 18 years of age due to the increased risk of severe adverse effects. However, your doctor may prescribe this medicine if the benefits significantly outweigh the risks. In such a case, the patient should be monitored closely for any adverse effects.

Use in the Elderly

This medicine should be used with caution in elderly patients due to the increased risk of severe adverse effects. Appropriate dose adjustments or replacement with a suitable alternative may be required in some cases based on the clinical condition.

Electrolyte imbalance

This medicine should be used with extreme caution in patients with acute or long-term electrolyte imbalance in the body due to the increased risk of worsening of the patient's condition. Regular monitoring of electrolyte levels should be done while receiving this medicine. An alternative treatment option should be considered in some cases based on the clinical condition.

Prolactin imbalance

This medicine should be used with caution since it may increase the risk of imbalance in the levels of prolactin, resulting in disturbances in the menstrual cycle in women. Prolonged use of this medicine can also result in breast like growth in men.

Kidney Disease

This medicine should be used with extreme caution in patients suffering from kidney diseases due to the increased risk of severe adverse effects. Close monitoring of kidney function is necessary while receiving this medicine. Appropriate dose adjustments or replacement with a suitable alternative may be required in some cases based on the clinical condition.

Liver Disease

This medicine should be used with extreme caution in patients suffering from liver diseases due to the increased risk of severe adverse effects. Close monitoring of liver function is necessary while receiving this medicine. Appropriate dose adjustments or replacement with a suitable alternative may be required in some cases based on the clinical condition.

Bone Fractures

Use of this medicine at high doses for a prolonged duration may increase the risk of bone fractures. This risk is especially higher in the elderly population and in women. Appropriate calcium and vitamin D supplementation may be required in some cases to reduce this risk.

Cardiovascular Diseases

This medicine should be used with caution in patients with a known history of cardiovascular disorders due to the increased risk of serious adverse effects. Close monitoring of heart function and vital signs, appropriate dose adjustments, or replacement with a suitable alternative may be necessary based on the clinical condition.

Other medicines

This combination medicine may interact with many other medicines and may cause severe adverse effects. Hence, it is advised that you inform the doctor about all your current medicines including any herbs and supplements before beginning treatment with this medicine.

Vitamin B12 deficiency

Long-term treatment with this medicine may decrease the absorption of Vitamin B12 in the body. This may cause vitamin B12 deficiency and associated symptoms. Appropriate vitamin B12 supplementation may be necessary based on the clinical condition.

Clostridium difficile-associated Diarrhea

Use of this medicine may be associated with Clostridium difficile-associated Diarrhea and it is recommended to undergo diagnostic tests for the same before taking this medicine. An alternative treatment option should be considered in some cases based on the clinical condition.

Driving or Operating machinery

Use of this medicine may cause dizziness in some patients. It is advised that you do not perform any activities such as driving a vehicle or operating machinery if you experience dizziness during treatment with this medicine.

Missed Dose

Take the missed dose as soon as you remember. If it is almost time for your next dose, skip the missed dose. Do not double your dose to make up for the missed one.

Overdose

Seek emergency medical treatment or contact the doctor in case of an overdose.
All drugs interact differently for person to person. You should check all the possible interactions with your doctor before starting any medicine.
Interaction with Alcohol

Description

Interaction with alcohol is unknown. It is advisable to consult your doctor before consumption.

Instructions

Interaction with alcohol is unknown. It is advisable to consult your doctor before consumption.
Interaction with Medicine

Cisapride

Erythromycin

Ketoconazole

Methotrexate

Tramadol

Warfarin

Nelfinavir

Bromocriptine

Disease interactions

Intestinal Disorders

This medicine should be used with extreme caution in patients having severe intestinal problems like internal bleeding, obstruction or perforation of the stomach and intestine may increase the risk of worsening the patient's condition. Appropriate dose adjustments or replacement with a suitable alternative may be necessary in some cases based on the clinical condition.

Liver Disease

This medicine should be used with caution in patients with a history of liver diseases or active liver diseases due to the increased risk of severe adverse effects. Close monitoring of liver function is necessary while receiving this medicine. Appropriate dose adjustments or replacement with a suitable alternative may be required in some cases based on the clinical condition.

Kidney Disease

This medicine should be used with caution in patients with kidney diseases due to the increased risk of severe adverse effects. Close monitoring of kidney function, appropriate dose adjustments, or replacement with a suitable alternative may be required in some cases based on the clinical condition.

Osteoporosis

This medicine should be used with extreme caution in patients with a history of osteoporosis due to the increased risk of fractures. This risk is especially higher with a high dose and prolonged use. Appropriate dose adjustments and more frequent clinical monitoring are required while using this medicine. An alternative treatment option may be necessary in some cases based on the clinical condition.

Hypomagnesemia

This medicine should be used with caution in patients who are prone to magnesium imbalances since it increases the risk of low magnesium levels. Report any unusual symptoms to the doctor immediately. Regular monitoring of magnesium levels, appropriate corrective measures, dose adjustments, or replacement with a suitable alternative may be necessary based on the clinical condition.
Food interactions
Information not available.
Lab interactions
Information not available.
This is not an exhaustive list of possible drug interactions. You should consult your doctor about all the possible interactions of the drugs you’re taking.
Take this medicine as instructed by the doctor. This medicine should be taken half an hour before food. Do not take in larger or smaller amounts than advised/prescribed. Consult the doctor if you experience any undesirable side effects. Ensure that the course of treatment is completed. Do not stop the use of this medicine without consulting your doctor.
Miscelleneous

To be taken before food

To be taken as instructed by doctor

May cause sleepiness

How it works
Domperidone works by blocking chemicals in the brain and the intestine. This causes improved movements and faster gastric emptying which helps in the prevention of vomiting. Esomeprazole works by interfering with the final step of acid release in the stomach. This helps in reducing the acidity in the stomach. Thus, this combination is better effective for the treatment of Gastroesophageal Reflux Disease (GERD).
Legal Status

Unknown

Unknown

Unknown

Unknown

Classification

Category

Proton pump inhibitors, Antiemetics

Schedule

Schedule H

Esomeprazole: MedlinePlus Drug Information [Internet]. Medlineplus.gov. 2017 [cited 30 March 2017]. Available from:

https://medlineplus.gov/druginfo/meds/a699054.html

[Internet]. 2019 [cited 23 April 2019]. Available from:

https://www.medicines.org.uk/emc/medicine/24915

[Internet]. 2019 [cited 23 April 2019]. Available from:

https://www.medicines.org.uk/emc/product/556/smpc
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Information on this page was last updated on 22 May 2019

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