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Natrilix 2.5 mg Tablet
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Natrilix 2.5 mg Tablet

Manufactured bySerdia Pharmaceuticals (India) Pvt. Ltd.
ContainsIndapamide
Description
Natrilix 2.5 mg Tablet is a diuretic medicine, used to reduce high blood pressure as well as edema (swelling) and fluid retention caused by heart diseases. It should be used with caution in patients with severe kidney diseases due to the increased risk of severe side effects. Frequent monitoring of blood pressure and electrolytes level is necessary while taking this medicine. Patients are advised to maintain a strict diet and exercise regimen along with this medicine to get the best possible effect.
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Side effectsConcernsUsageRelated products

Substitutes

List of substitutes for Natrilix 2.5 mg Tablet

Indap 2.5 mg Tablet
Orchid Chemicals & Pharmaceuticals Ltd.
Inditor 2.5 mg Tablet
Ipca Laboratories Pvt. Ltd.
Lorvas 2.5 mg Tablet
Torrent Pharmaceuticals Ltd.
Natritor 2.5 mg Tablet
Ipca Laboratories Pvt. Ltd.

Side effects

Major & minor side effects for Natrilix 2.5 mg Tablet

  • Dry mouth
  • Hypotension
  • Itching or rash
  • Abdominal pain
  • Dizziness
  • Headache
  • Muscle cramps
  • Loss of appetite
  • Nausea and vomiting
  • Irregular heartbeat

Uses of Natrilix 2.5 mg Tablet

What is it prescribed for?

  • Edema
  • Hypertension
Read More
Concerns

Commonly asked questions

  • How long does it take for this medicine to take effect?
    The effect of this medicine can be observed within 1 to 3 hours of administration of the dose.
  • How long do the effects of this medicine last?
    The effect of this medicine lasts for an average duration of 8 to 12 hours.
  • Is it safe to consume alcohol while taking this medicine?
    Consumption of alcohol is not recommended while you are taking this medicine. The combination may increase the risk of dizziness, fainting, and very low blood pressure. It is advised that you do not perform any activities that require high mental alertness such as driving a vehicle or operating machinery if you consume alcohol during treatment with this medicine. Report any incidence of breathing difficulty or dizziness to the doctor immediately.
  • Is this a habit forming medicine?
    No habit-forming tendency has been reported.
  • Can this medicine be taken during pregnancy?
    This medicine is not recommended for use in pregnant women unless absolutely necessary. All the risks and benefits should be discussed with the doctor before taking this medicine. Your doctor may prescribe a safer alternative based on your clinical condition.
  • Can this medicine be taken while breast-feeding?
    This medicine is not recommended for use in breastfeeding women unless absolutely necessary. All the risks and benefits should be discussed with the doctor before taking this medicine. Your doctor may advise you to discontinue breastfeeding or to discontinue the drug based on your clinical condition.

Allergy

This medicine is not recommended for use in patients with a known allergy to indapamide, or any other inactive ingredients present in the formulation.

Anuria

This medicine is not recommended for use in patients with anuria, a condition where the kidney is unable to produce urine.
Warnings for special population

Pregnancy

This medicine is not recommended for use in pregnant women unless absolutely necessary. All the risks and benefits should be discussed with the doctor before taking this medicine. Your doctor may prescribe a safer alternative based on your clinical condition.

Breast-feeding

This medicine is not recommended for use in breastfeeding women unless absolutely necessary. All the risks and benefits should be discussed with the doctor before taking this medicine. Your doctor may advise you to discontinue breastfeeding or to discontinue the drug based on your clinical condition.
General warnings

Liver disease

This medicine should be used with extreme caution in patients suffering from liver diseases due to an increase in the risk of serious adverse effects including coma. Close monitoring of liver function is advised while taking this medicine. Report any symptoms of confusion or jaundice to the doctor on priority. Therapy with medicine may need to be discontinued based on the clinical condition.

Kidney disease

This medicine may cause Azotemia in patients with a known history of severe kidney disease. Close monitoring of kidney function is necessary while taking this medicine. Appropriate dose adjustments or replacement with a suitable alternative may be required based on the clinical condition.

Volume and electrolyte depletion

This medicine may alter the blood volume levels and electrolytes levels. This may cause dizziness, dry mouth, and acid-base imbalance. Close monitoring of blood pressure and electrolyte levels is necessary while taking this medicine. Report any symptoms such as weakness, lethargy, muscle pain, drowsiness, dizziness, irregular heartbeat, etc. to the doctor immediately. Appropriate corrective measures and dose adjustments may be required based on the clinical condition of the patient.

Lupus erythematosus

This medicine should be used with caution in patients with lupus erythematosus due to the increased risk of worsening of the patient's condition. Replacement with a suitable alternative should be considered based on the clinical condition of the patient.

Sports

Athletes are advised not to indulge in certain sports while using this medicine. Archery, racing, shooting, and other high-risk sports should be avoided. Sportspersons should refer to the list of medicines published by the World Anti-Doping Agency (WADA) which are not to be taken while participating in specific sports events.

Driving or operating machinery

This medicine may cause dizziness or drowsiness in some patients. It is advised that you do not perform any activities that require high mental alertness like driving a vehicle or operating machinery if you experience any of these symptoms during treatment with this medicine.

Missed Dose

Take the missed dose as soon as you remember. If it is almost time for your next scheduled dose, skip the missed dose. Do not double your dose to make up for the missed one.

Overdose

Seek emergency medical treatment or contact the doctor in case of an overdose.
All drugs interact differently for person to person. You should check all the possible interactions with your doctor before starting any medicine.
Interaction with Alcohol

Description

N/A

Instructions

Consumption of alcohol is not recommended while you are taking this medicine. The combination may increase the risk of dizziness, fainting, and very low blood pressure. It is advised that you do not perform any activities that require high mental alertness such as driving a vehicle or operating machinery if you consume alcohol during treatment with this medicine. Report any incidence of breathing difficulty or dizziness to the doctor immediately.
Interaction with Medicine

Amitriptyline

Cisapride

Lithium

Amiodarone

Insulin

Nonsteroidal anti-inflammatory medicines

Disease interactions

Asthma

This medicine is not recommended for use in patients with a history of asthma due to the increased risk of worsening of the patient's condition. Replacement with a suitable alternative may be necessary based on the clinical condition.

Diabetes

This medicine should be used with caution in patients with a known history of diabetes mellitus due to the increased risk of altered blood glucose levels. Close monitoring of blood glucose levels is advised for such patients. Appropriate dose adjustments or replacement with a suitable alternative may be required based on the clinical condition.

Hyperlipidemia

This medicine should be used with caution in patients with hyperlipidemia since it may further increase the blood triglycerides and cholesterol levels. Close monitoring of blood triglycerides and cholesterol levels is necessary while receiving this medicine. Appropriate dose adjustments or replacement with a suitable alternative may be necessary based on the clinical condition.

Hyperparathyroidism

This medicine should be used with caution in patients with hyperparathyroidism due to the increased risk of worsening of the patient's condition. Close monitoring of blood calcium levels is recommended for such patients. Replacement with a suitable alternative may be required based on the clinical condition.

Hyperuricemia

This medicine should be used with caution in patients with hyperuricemia due to the increased risk of worsening of the patient's condition. Close monitoring of uric acid level is recommended for such patients. Appropriate dose adjustments or replacement with a suitable alternative may be necessary based on the clinical condition.

Liver Disease

This medicine should be used with extreme caution in patients suffering from liver diseases due to an increase in the risk of serious adverse effects including coma. Close monitoring of liver function tests is necessary while receiving this medicine. Report any symptoms of confusion or jaundice to the doctor on priority. Appropriate dose adjustments or replacement with a suitable alternative may be required in some cases based on the clinical condition.

Kidney Disease

This medicine should be used with caution in patients with a history of kidney diseases due to the increased risk of severe adverse effects. Close monitoring of kidney function tests is necessary while receiving this medicine. Appropriate dose adjustments or replacement with a suitable alternative may be required in some cases based on the clinical condition.
Food interactions
Information not available.
Lab interactions

Thyroid function tests

This medicine may decrease the serum protein-bound iodine levels. This factor should be taken into account when interpreting thyroid function tests' results. It is advised that you inform the doctor about all your current medicines including herbs and supplements before undergoing thyroid function tests.
This is not an exhaustive list of possible drug interactions. You should consult your doctor about all the possible interactions of the drugs you’re taking.
Take this medicine as advised by your doctor. Do not take in larger or smaller amounts than prescribed. Take this medicine at daytime to prevent sleep disturbance. Drink an adequate amount of water. Monitoring of kidney function and electrolyte levels is necessary while taking this medicine. Ensure that the course of treatment is completed. Report any adverse effects to the doctor on priority.
Miscelleneous

Can be taken with or without food, as advised by your doctor

To be taken as instructed by doctor

May cause sleepiness

How it works
This medicine works by increasing the excretion of water and sodium from the kidneys. This helps in bringing down the blood pressure as well as swelling.
Legal Status

Approved

Approved

Approved

Approved

Classification

Category

Thiazide diuretics

Schedule

Schedule H

[Internet]. Medicines.org.uk. 2020 [cited 3 June 2020]. Available from:

https://www.medicines.org.uk/emc/files/pil.4188.pdf

Indapamide: MedlinePlus Drug Information [Internet]. Medlineplus.gov. 2020 [cited 3 June 2020]. Available from:

https://medlineplus.gov/druginfo/meds/a684062.html

Indapamide - DrugBank [Internet]. Drugbank.ca. 2020 [cited 3 June 2020]. Available from:

https://www.drugbank.ca/drugs/DB00808

INDAPAMIDE TABLETS, USP [Internet]. Dailymed.nlm.nih.gov. 2020 [cited 3 June 2020]. Available from:

https://dailymed.nlm.nih.gov/dailymed/fda/fdaDrugXsl.cfm?setid=a8a4ec2c-9d4b-482b-ad29-88185c96db74&type=display
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Information on this page was last updated on 11 Jun 2020

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