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Metolactone (50/2.5 mg) Tablet
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Metolactone (50/2.5 mg) Tablet

Manufactured byCentaur Pharmaceuticals Pvt. Ltd.
ContainsSpironolactone (50 mg) + Metolazone (2.5 mg)
Description
Metolactone (50/2.5 mg) Tablet is a combination medicine used in the treatment of high blood pressure and edema associated with conditions such as congestive heart failure, nephrotic syndrome, and liver cirrhosis. Frequent monitoring of blood pressure and electrolytes level is necessary during treatment with this medicine.
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Side effectsConcernsUsageRelated products

Side effects

Major & minor side effects for Metolactone (50/2.5 mg) Tablet

  • Chest pain
  • Dry mouth
  • Diarrhea
  • Joint pain, stiffness, and swelling
  • Trembling
  • Increased urination
  • Abdominal and stomach pain
  • Weakness
  • Dizziness
  • Irregular heartbeat
  • Headache
  • Skin rash
  • Gynecomastia

Uses of Metolactone (50/2.5 mg) Tablet

What is it prescribed for?

  • Hypertension
  • Congestive Heart Failure
  • Edema associated with liver cirrhosis
  • Edema associated with Nephrotic Syndrome
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Concerns

Commonly asked questions

  • How long does it take for this medicine to take effect?
    The effect of this medicine can be observed within 1 hour of administration of the dose.
  • How long do the effects of this medicine last?
    The effect of this medicine lasts for an average duration of 2 to 3 days.
  • Is it safe to consume alcohol while taking this medicine?
    Consumption of alcohol is not recommended during treatment with this medicine due to the increased risk of side effects such as dizziness, lightheadedness, and fainting. It is advised that you do not perform any activities that require high mental alertness such as driving a vehicle or operating machinery if you consume alcohol during treatment with this medicine.
  • Is this a habit forming medicine?
    No habit-forming tendencies were reported.
  • Can this medicine be taken during pregnancy?
    This medicine is not recommended for use in pregnant women unless absolutely necessary. All the risks and benefits should be discussed with the doctor before taking this medicine.
  • Can this medicine be taken while breast-feeding?
    This medicine is not recommended for use in breastfeeding women unless absolutely necessary. All the risks and benefits should be discussed with the doctor before taking this medicine. Your doctor may advise you to discontinue breastfeeding or to discontinue the drug based on your clinical condition.

Allergy

This medicine is not recommended for use in patients with a known allergy to spironolactone, metolazone, or any other inactive ingredients present along with these medicines.

Severe liver impairment

This medicine is not recommended for use in patients with a known history of severe liver impairment due to the increased risk of hepatic coma and pre-coma. It is not recommended for use in patients with hepatic coma or pre-coma due to the increased risk of worsening of the patient's condition.

Anuria

This medicine is not recommended for use in patients with anuria, a condition where the kidney is unable to produce urine.
Warnings for special population

Pregnancy

This medicine is not recommended for use in pregnant women unless absolutely necessary. All the risks and benefits should be discussed with the doctor before taking this medicine.

Breast-feeding

This medicine is not recommended for use in breastfeeding women unless absolutely necessary. All the risks and benefits should be discussed with the doctor before taking this medicine. Your doctor may advise you to discontinue breastfeeding or to discontinue the drug based on your clinical condition.
General warnings

Hepatic dysfunction

This medicine should be used with extreme caution in patients with liver impairment due to an increase in the risk of serious adverse effects including coma. Close monitoring of liver function is advised while taking this medicine. Report any symptoms of confusion or jaundice to the doctor on priority. Appropriate dose adjustments or replacement with a suitable alternative may be necessary based on the clinical condition.

Renal diseases

This medicine may cause Azotemia in patients with a known history of severe renal diseases. Close monitoring of kidney function is necessary while taking this medicine. Appropriate dose adjustments should be done based on the renal function of the patient.

Hyperkalemia

This medicine may increase the potassium levels in the blood (hyperkalemia). This may cause serious side effects such as fatal cardiac rhythm irregularities. It is advised to avoid potassium-rich foods (potatoes, bananas) and other medicines that may increase potassium levels (ACE inhibitors and potassium supplements) during treatment with this medicine.

Volume depletion and Electrolyte imbalance

This medicine may alter the blood volume and electrolyte levels in some patients. This may cause dizziness, dry mouth, and acid-base imbalance. This risk is especially higher in patients suffering from kidney and liver diseases. Close monitoring of blood pressure and electrolyte levels is recommended for such patients. Appropriate dose adjustments or replacement with a suitable alternative may be required based on the clinical condition.

Missed Dose

Take the missed dose as soon as you remember. If it is almost time for your next scheduled dose, skip the missed dose. Do not double your dose to make up for the missed one.

Overdose

Seek emergency medical treatment or contact the doctor in case of an overdose.
All drugs interact differently for person to person. You should check all the possible interactions with your doctor before starting any medicine.
Interaction with Alcohol

Description

N/A

Instructions

Consumption of alcohol is not recommended during treatment with this medicine due to the increased risk of side effects such as dizziness, lightheadedness, and fainting. It is advised that you do not perform any activities that require high mental alertness such as driving a vehicle or operating machinery if you consume alcohol during treatment with this medicine.
Interaction with Medicine

Metformin

Insulin

Angiotensin converting enzyme inhibitors (ACEI's)

Antidepressants

Nonsteroidal anti-inflammatory medicines

Disease interactions

Diabetes

This medicine should be used with caution in patients with a known history of diabetes mellitus due to the increased risk of altered blood glucose levels. Close monitoring of blood glucose levels is advised for such patients. Appropriate dose adjustments or replacement with a suitable alternative may be required based on the clinical condition.

Hyperuricemia

This medicine should be used with caution in patients with a history of gout or chronic renal failure due to the increased risk of hyperuricemia. Close monitoring of uric acid level is recommended for such patients. Appropriate dose adjustments or replacement with a suitable alternative may be necessary based on the clinical condition of the patient.

Electrolyte imbalance

This medicine should be used with caution in patients prone to electrolyte imbalances since it may worsen the patient's condition. Close monitoring of electrolyte levels is recommended for such patients. Any electrolyte imbalances should be corrected before initiating therapy. Appropriate dose adjustments or replacement with a suitable alternative may be required based on the clinical condition.

Impaired kidney function

This medicine is not recommended for use in patients with a known history of kidney diseases due to the increased risk of worsening of the patient's condition. Renal function should be assessed before initiating treatment. Replacement with a suitable alternative may be necessary based on the clinical condition.
Food interactions
Information not available.
Lab interactions
Information not available.
This is not an exhaustive list of possible drug interactions. You should consult your doctor about all the possible interactions of the drugs you’re taking.
Take this medicine exactly as advised by your doctor. Do not take in larger amounts than prescribed. It is advised to take this medicine at daytime to prevent sleep disturbance. Drink an adequate amount of water. Monitoring of kidney function and electrolytes levels is necessary while taking this medicine. Report any adverse effects to the doctor on priority. Do not stop the use of this medicine without consulting your doctor.
Miscelleneous

Can be taken with or without food, as advised by your doctor

To be taken as instructed by doctor

May cause sleepiness

How it works
Spironolactone and metolazone both increase the excretion of water and sodium through the urine. Their combination is thus effective in reducing blood pressure, edema, and the strain on the heart.
Legal Status

Approved

Unknown

Unknown

Unknown

Classification

Category

Antihypertensive combinations, Potassium sparing diuretics with thiazides

Schedule

Schedule H

DailyMed - Spironolactone tablet, film coated [Internet]. Dailymed.nlm.nih.gov. 2017 [cited 5 June 2017]. Available from:

https://dailymed.nlm.nih.gov/dailymed/drugInfo.cfm?setid=a7510768-8a52-4230-6aa0-b0d92d82588f

DailyMed - Metolazone tablet [Internet]. Dailymed.nlm.nih.gov. 2017 [cited 3 August 2017]. Available from:

https://dailymed.nlm.nih.gov/dailymed/drugInfo.cfm?setid=0b619826-2567-49d7-8972-b6da5e4467df

Metolazone - DrugBank [Internet]. Drugbank.ca. 2017 [cited 3 August 2017]. Available from:

https://www.drugbank.ca/drugs/DB00524

Spironolactone - DrugBank [Internet]. Drugbank.ca. 2017 [cited 26 September 2017]. Available from:

https://www.drugbank.ca/drugs/DB00421
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Information on this page was last updated on 9 Oct 2017

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We’ve made all possible efforts to ensure that the information provided here is accurate, up-to-date and complete, however, it should not be treated as a substitute for professional medical advice, diagnosis or treatment. Practo only provides reference source for common information on medicines and does not guarantee its accuracy or exhaustiveness. The absence of a warning for any drug or combination thereof, should not be assumed to indicate that the drug or combination is safe, effective, or appropriate for any given patient. Practo does not assume any responsibility for any aspect of healthcare administered with the aid of information provided above. If you have any doubts about your medication then we strongly recommend that you consult with your doctor, nurse or healthcare provider. See detailed T&C here.