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Metaglez (500/5 mg) Tablet
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Metaglez (500/5 mg) Tablet

Manufactured byAristo Pharmaceuticals Pvt. Ltd.
ContainsMetformin (500 mg) + Glipizide (5 mg)
Description
Metaglez (500/5 mg) Tablet is a combination of Metformin and Glipizide. It is an anti-diabetic medicine used in the treatment of Type 2 Diabetes Mellitus (a condition in which your blood sugar levels are high because your body does not use the insulin hormone it makes properly to move sugar from the blood into the cells). This medicine works by improving the body’s response to insulin (a hormone that enables your body to use sugar) and decreasing sugar production in the liver. Metaglez (500/5 mg) Tablet shows common side effects such as stuffy nose, sore throat, stomach upset, nausea, diarrhoea, headache, dizziness, or low blood sugar levels. Consult your doctor if these side effects persist or worsen. Metaglez (500/5 mg) Tablet may be taken with or without food. Take the medicine as per the prescription. For ease of remembering, take it around the same time every day. Do not discontinue the use of this medicine unless advised by your doctor, even if your sugar levels are normal. If you stop taking the medicine suddenly, it may worsen your condition and/or lead to further complications. Metaglez (500/5 mg) Tablet is not recommended if you are allergic to it. It is not recommended if you have severe kidney problems or condition that causes an increased acid level in the body such as metabolic acidosis and diabetic ketoacidosis. It should be taken with caution if you have liver conditions, congestive heart failure (inability of the heart to pump an adequate amount of blood), or deficiency of glucose-6-phosphate dehydrogenase (an enzyme that prevents premature destruction and damage of red blood cells). Metaglez (500/5 mg) Tablet is not recommended for use in children below 18 years of age due to the lack of safety and efficacy data. If you are pregnant or are breastfeeding, consult your doctor before taking this medicine. It should be used with caution if you are 65 years of age or above.
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Side effectsConcernsUsage

Side effects

Major & minor side effects for Metaglez (500/5 mg) Tablet

  • Anxiety
  • Blurred vision
  • Chills
  • Confusion
  • Fast heartbeat
  • Headache
  • Nausea
  • Nervousness
  • Sore throat
  • Unusual tiredness and weakness
  • Stomach upset
  • Low blood sugar levels

Uses of Metaglez (500/5 mg) Tablet

What is it prescribed for?

  • Type II Diabetes Mellitus
Read More
Concerns

Commonly asked questions

  • How long does it take for this medicine to take effect?
    The time required by Metaglez (500/5 mg) Tablet to show its effect is not clinically established.
  • How long do the effects of this medicine last?
    The time duration for which Metaglez (500/5 mg) Tablet remains effective in the body is not clinically established.
  • Is it safe to consume alcohol while taking this medicine?
    Consumption of alcohol is not recommended during treatment with Metaglez (500/5 mg) Tablet due to the increased risk of side effects such as increased acid levels in the blood and low as well as high blood sugar levels.
  • Is this a habit forming medicine?
    No habit-forming tendency has been reported for Metaglez (500/5 mg) Tablet.
  • Can this medicine be taken during pregnancy?
    Metaglez (500/5 mg) Tablet is not recommend for use during pregnancy unless absolutely necessary. Hence consult your doctor if you are pregnant.
  • Can this medicine be taken while breast-feeding?
    Small amounts of Metaglez (500/5 mg) Tablet may pass into breastmilk. Hence if you are breastfeeding, consult your doctor before taking this medicine.

Allergy

Avoid taking Metaglez (500/5 mg) Tablet if you are allergic to it. Seek immediate medical attention if you notice any symptoms such as skin rash, itching/swelling (especially of the face/tongue/throat), severe dizziness, breathing difficulty, etc.

Type I Diabetes mellitus

Metaglez (500/5 mg) Tablet is not recommended if you have type I diabetes mellitus (a condition in which your body is unable to produce a sufficient amount of insulin to lower the blood sugar level).

Metabolic Acidosis and diabetic ketoacidosis

Metaglez (500/5 mg) Tablet is not recommended for use if you have conditions that may cause an increased level of acids in your body such as metabolic acidosis or diabetic ketoacidosis.

Severe kidney impairment

Metaglez (500/5 mg) Tablet is not recommended if you have severe kidney problems as it may worsen your condition.
Warnings for special population

Pregnancy

Metaglez (500/5 mg) Tablet is not recommend for use during pregnancy unless absolutely necessary. Hence consult your doctor if you are pregnant.

Breast-feeding

Small amounts of Metaglez (500/5 mg) Tablet may pass into breastmilk. Hence if you are breastfeeding, consult your doctor before taking this medicine.
General warnings

Stress

Metaglez (500/5 mg) Tablet should be used with caution if you are exposed to stressful conditions such as fever, trauma, surgery, or accidents, as it may not be effective in controlling blood sugar levels in these conditions. Replacement with a suitable alternative may be recommended by your doctor.

Liver disease

Metaglez (500/5 mg) Tablet should be used with caution if you have liver problems, as it can worsen your condition.

Kidney disease

Metaglez (500/5 mg) Tablet should be used with caution if you have mild to moderate kidney conditions, as it can cause lactic acidosis (accumulation of lactic acid in the bloodstream). Appropriate dose adjustments or replacement with a suitable alternative will be done by your doctor based on your clinical condition.

Use in children

Metaglez (500/5 mg) Tablet is not recommended for use in children below 18 years of age due to the lack of safety and efficacy data.

Missed Dose

Do not miss the dose of Metaglez (500/5 mg) Tablet. In case you miss a dose, take it as soon as you remember. However, if it is time for the next dose, then skip the missed dose. Do not double the dose to make up for the missed one.

Overdose

Do not take more than the prescribed dose of Metaglez (500/5 mg) Tablet. Seek emergency medical treatment in case of an overdose.
All drugs interact differently for person to person. You should check all the possible interactions with your doctor before starting any medicine.
Interaction with Alcohol

Description

N/A

Instructions

Consumption of alcohol is not recommended during treatment with Metaglez (500/5 mg) Tablet due to the increased risk of side effects such as increased acid levels in the blood and low as well as high blood sugar levels.
Interaction with Medicine

Atenolol

Estradiol

Gatifloxacin

Iodinated Contrast Media

Disease interactions

Heart Disease

Metaglez (500/5 mg) Tablet should be used with caution if you have heart conditions. Follow all the instructions given by your doctor.

Hypoglycaemia

Metaglez (500/5 mg) Tablet should be used with caution as it may cause hypoglycaemia (abnormally low levels of sugar in the blood). Follow all the instructions given by your doctor.

Hemolytic Anaemia/G6PD Deficiency

Metaglez (500/5 mg) Tablet should be used with caution if you have a deficiency of glucose-6-phosphate dehydrogenase (an enzyme that prevents premature destruction of red blood cells). This medicine may increase the risk of haemolytic anaemia (abnormal breakdown of red blood cells) in such a condition.

Vitamin B12 deficiency

Metaglez (500/5 mg) Tablet interferes with the absorption of Vitamin B12 in your body. Hence, this medicine should be used with caution if you have vitamin B12 deficiency. Inform your doctor if you are taking vitamin B12 supplements before starting the treatment.
Food interactions
Information not available.
Lab interactions
Information not available.
This is not an exhaustive list of possible drug interactions. You should consult your doctor about all the possible interactions of the drugs you’re taking.
Take Metaglez (500/5 mg) Tablet as prescribed by your doctor. It may be taken with or without food. Do not break, crush, or chew the tablet. Swallow it as a whole with an adequate amount of water. Do not take in larger or smaller amounts than prescribed. Your doctor may change the dose over time based on the therapeutic response and clinical condition. Do not discontinue the medicine without consulting your doctor, even if your sugar level is normal. Regular monitoring of blood sugar levels is recommended during treatment with this medicine. Consult your doctor if you experience any undesirable effects that persist or worsen. Always carry a sugar candy with you to counteract the unexpected lowering of blood sugar levels.
Miscelleneous

Can be taken with or without food, as advised by your doctor

To be taken as instructed by doctor

Does not cause sleepiness

How it works
Metaglez (500/5 mg) Tablet is a combination of Metformin and Glipizide. It works by improving the body’s response to insulin (a hormone that enables your body to use sugar) and decreasing sugar production in the liver.
Legal Status

Approved

Approved

Unknown

Unknown

Classification

Category

Antidiabetic combinations

Schedule

Schedule H

Accessdata.fda.gov. 2022. [online] Available at: [Accessed 29 July 2022].

https://www.accessdata.fda.gov/drugsatfda_docs/label/2008/021460s007lbl.pdf

Hpra.ie. 2022. [online] Available at: [Accessed 29 July 2022].

https://www.hpra.ie/img/uploaded/swedocuments/2204718.PA0577_132_001.11943e2a-fbee-4282-b19d-6e18b5d1544b.000001PIL.180529.pdf
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Information on this page was last updated on 15 Sep 2022

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