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Lupigyl 0.5% Infusion

Manufactured byLupin Ltd.
Description
Lupigyl 0.5% Infusion is an antibiotic medicine that contains Metronidazole. It is used in the treatment of infections of the stomach, intestines, liver, lungs, heart, vagina, and skin. It is also used in the combination with other antibiotics in surgical prophylaxis. This medicine acts by killing the bacteria and preventing the spread of infection. Lupigyl 0.5% Infusion may show some common side effects such as pain at the site of injection, dizziness, stomach ache, diarrhoea, metallic taste in the mouth, etc. These side effects may subside by themselves. Consult your doctor if they bother you for a longer time or worsen. Do not consume alcohol during therapy with Lupigyl 0.5% Infusion as this may cause serious side effects. Do not receive this infusion if you are allergic to it. Lupigyl 0.5% Infusion is administered intravenously by a healthcare professional in a hospital setting. Hence, do not self administer. The dose and the duration of the treatment will be decided by your doctor based on your condition. Abrupt discontinuation may make this medicine ineffective when used for future infections. If you still feel unwell after completing your antibiotic course, inform your doctor. Lupigyl 0.5% Infusion may not be suitable for all people. Inform your doctor if you have liver problems, low blood count, and your ongoing medications. Also, inform your doctor if you are pregnant or breastfeeding before taking this medicine.

Side effects

Major & minor side effects for Lupigyl 0.5% Infusion

  • Burning or tingling sensation of hands and feet
  • Confusion
  • Dizziness
  • Headache
  • Skin Rash
  • Constipation
  • Dark urine
  • Fast heartbeat
  • Dry mouth
  • Nausea or vomiting
  • Stomach ache
  • Pain at the injection site
  • Diarrhoea
  • Change in taste/ Metallic taste

Uses of Lupigyl 0.5% Infusion

What is it prescribed for?

  • Bacterial infections
  • Surgical prophylaxis
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Concerns

Commonly asked questions

  • How long does it take for this medicine to take effect?
    Lupigyl 0.5% Infusion may start showing its effect within 1 hour of administration.
  • How long do the effects of this medicine last?
    The duration of action for Lupigyl 0.5% Infusion is about 12 hours.
  • Is it safe to consume alcohol while taking this medicine?
    Avoid consuming alcohol while on treatment with Lupigyl 0.5% Infusion as it may cause symptoms of a fast heartbeat, warmth, headache, and breathing difficulty.
  • Is this a habit forming medicine?
    No habit-forming tendency has been reported for Lupigyl 0.5% Infusion.
  • Can this medicine be taken during pregnancy?
    Lupigyl 0.5% Infusion is considered safe to be used in pregnancy. However, if you are pregnant, inform your doctor before taking this medicine.
  • Can this medicine be taken while breast-feeding?
    Lupigyl 0.5% Infusion is not recommended for use in breastfeeding. However, if you are breastfeeding, inform your doctor before taking this medicine. if this medicine is used, your infant should be observed for symptoms such as diarrhoea or diaper rash.

Allergy

Avoid receiving Lupigyl 0.5% Infusion if you are allergic to it. Serious allergic reactions to this medicine are rare. However, seek immediate medical attention if you notice any symptoms such as skin rash, itching/swelling (especially of the face/tongue/throat), severe dizziness, breathing difficulty, etc.
Warnings for special population

Pregnancy

Lupigyl 0.5% Infusion is considered safe to be used in pregnancy. However, if you are pregnant, inform your doctor before taking this medicine.

Breast-feeding

Lupigyl 0.5% Infusion is not recommended for use in breastfeeding. However, if you are breastfeeding, inform your doctor before taking this medicine. if this medicine is used, your infant should be observed for symptoms such as diarrhoea or diaper rash.
General warnings

Blood cell count

Taking Lupigyl 0.5% Infusion for prolonged periods can decrease total blood cell count. Your doctor may suggest tests to monitor your blood count if necessary based on your condition.

Neurologic toxicity

Lupigyl 0.5% Infusion should be taken with caution as it may show side effects like convulsions (a sudden, irregular movement of the body, caused by involuntary contraction of muscles), peripheral neuropathy (pain due to nerve damage), headache, and dizziness.

Liver disease

Lupigyl 0.5% Infusion should be taken with caution if you have liver problems due to the increased risk of liver damage. Your doctor may suggest tests for monitoring your liver condition if necessary while on treatment with this medicine.

Dialysis

Dialysis is the procedure to remove waste products from your blood when the kidney fails to do it. The desired effect of Lupigyl 0.5% Infusion is not achieved if you are undergoing dialysis. Your doctor may schedule the dose for administration after the dialysis procedure or supplemental doses can be given after dialysis.

Antibiotic resistance

Finish your entire course of treatment with Lupigyl 0.5% Infusion, even if the condition gets better to avoid antibiotic resistance (a condition where microbes evolve mechanisms that protect them from the effects of antibiotics). If you still feel unwell after completing your antibiotic course, consult your doctor.

Driving or operating machines

Lupigyl 0.5% Infusion may cause dizziness, confusion, or disorientation in some people. Hence, do not perform activities that require your concentration like driving vehicles or operating machines if you experience any of these symptoms.

Missed Dose

Since Lupigyl 0.5% Infusion is administered in the hospital setting by a qualified healthcare professional, the likelihood of missing a dose is very low.

Overdose

Since Lupigyl 0.5% Infusion is administered in the hospital setting by a qualified healthcare professional, the chances of an overdose are very low. However, your doctor will take further measures if an overdose is suspected.
All drugs interact differently for person to person. You should check all the possible interactions with your doctor before starting any medicine.
Interaction with Alcohol

Description

N/A

Instructions

Avoid consuming alcohol while on treatment with Lupigyl 0.5% Infusion as it may cause symptoms of a fast heartbeat, warmth, headache, and breathing difficulty.
Interaction with Medicine

Warfarin

Ethinyl Estradiol

Atorvastatin

Disulfiram

Phenytoin

Lithium

Disease interactions

Neurologic toxicity

Lupigyl 0.5% Infusion should be taken with caution as it may show side effects like convulsions (a sudden, irregular movement of the body, caused by involuntary contraction of muscles), peripheral neuropathy (pain due to nerve damage), headache, and dizziness.

Liver disease

Lupigyl 0.5% Infusion should be taken with caution if you have liver problems due to the increased risk of liver damage. Your doctor may suggest tests for monitoring your liver condition if necessary while on treatment with this medicine.
Food interactions
Information not available.
Lab interactions
Information not available.
Lupigyl 0.5% Infusion is administered by a qualified healthcare professional in a clinical or hospital setting. Inform your doctor if you have liver problems or other medical conditions before taking this infusion. Also, inform your doctor if you are pregnant or breastfeeding before taking Lupigyl 0.5% Infusion. Consult your doctor if you experience any undesirable effects after taking this medicine.
Miscelleneous

Usage does not depend on food timings

To be taken as instructed by doctor

May cause sleepiness

How it works
Lupigyl 0.5% Infusion works by interfering with the DNA formation in the bacterial cell and stopping the protein synthesis. This action kills the bacteria and prevents infection from spreading.
Legal Status

Approved

Approved

Approved

Approved

Classification

Category

Amebicides, Miscellaneous antibiotics

Schedule

Schedule H

2021. [online] Available at: < [Accessed 6 October 2021].

https://www.nps.org.au/medicine-finder/dbl-metronidazole-intravenous-infusion>

Medicines.org.uk. 2021. Metronidazole 500 mg / 100 ml Intravenous Infusion - Summary of Product Characteristics (SmPC) - (emc). [online] Available at: < [Accessed 6 October 2021].

https://www.medicines.org.uk/emc/product/1842#gref>

Medicines.org.uk. 2021. Metronidazole Tablets 500 mg - Summary of Product Characteristics (SmPC) - (emc). [online] Available at: < [Accessed 28 October 2021].

https://www.medicines.org.uk/emc/product/5882/smpc#gref>

Pubchem.ncbi.nlm.nih.gov. 2021. Metronidazole. [online] Available at: < [Accessed 28 October 2021].

https://pubchem.ncbi.nlm.nih.gov/compound/Metronidazole>
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Information on this page was last updated on 29 Oct 2021

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