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Genval CR-500 Tablet

Manufactured byGENTECH HEALTHCARE LTD
ContainsSodium Valproate (333 mg) + Valproic Acid (145 mg)
Description

Genval CR-500 Tablet is an anticonvulsant medication that is used for the treatment of all types of epilepsies, a brain disorder characterized by uncontrolled jerking movements and loss of consciousness. Take this medicine at the same time regularly.

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Side effects

Major & minor side effects for Genval CR-500 Tablet

  • Nausea or Vomiting
  • Diarrhea
  • Blurred vision
  • Dizziness
  • Weight gain
  • Body pain
  • Skin rash
  • Sneezing
  • Dry or scaly skin
  • Urinary incontinence

Uses of Genval CR-500 Tablet

What is it prescribed for?

  • Epilepsy
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Concerns

Commonly asked questions

  • How long does it take for this medicine to take effect?
    The amount of time required for this medicine to show its action is not clinically established.
  • How long do the effects of this medicine last?
    The amount of time for which this medicine remains active in the body is not clinically established.
  • Is it safe to consume alcohol while taking this medicine?
    Consumption of alcohol is not recommended during treatment with this medicine due to the increased risk of side effects such as dizziness, difficulty in concentration, drowsiness, etc. It is advised that you do not perform any activities that require high mental alertness such as driving a vehicle or operating machinery if you consume alcohol during treatment with this medicine.
  • Is this a habit forming medicine?
    No habit forming tendency has been reported.
  • Can this medicine be taken during pregnancy?
    This medicine is not recommended for use in pregnant women except in life-threatening conditions. All the risks and benefits should be discussed with the doctor before taking this medicine. Your doctor may prescribe a safer alternative based on your clinical condition.
  • Can this medicine be taken while breast-feeding?
    This medicine is not recommended for use in breastfeeding women unless absolutely necessary. All the risks and benefits should be discussed with the doctor before taking this medicine. Your doctor may advise you to discontinue breastfeeding or to discontinue the drug based on your clinical condition.

Allergy

This medicine is not recommended for use in patients with a known allergy to sodium valproate, valproic acid, or any other inactive ingredients present along with the formulation.

Active and/or severe liver disease

This medicine is not recommended for use in patients with active and/or severe liver diseases.

Urea cycle disorders

This medicine is not recommended for use in patients with urea cycle disorders (high ammonium levels in the blood) or family history of urea cycle disorder.

Mitochondrial disorders

This medicine is not recommended for use in patients and children who are suspected to have the mitochondrial disorder (POLG e.g Alpers-Huttenlocher Syndrome).

Porphyria

This medicine is not recommended for use in patients suffering from porphyria, a disorder where there is an over-accumulation of porphyrin in the body.
Warnings for special population

Pregnancy

This medicine is not recommended for use in pregnant women except in life-threatening conditions. All the risks and benefits should be discussed with the doctor before taking this medicine. Your doctor may prescribe a safer alternative based on your clinical condition.

Breast-feeding

This medicine is not recommended for use in breastfeeding women unless absolutely necessary. All the risks and benefits should be discussed with the doctor before taking this medicine. Your doctor may advise you to discontinue breastfeeding or to discontinue the drug based on your clinical condition.
General warnings

Pancreatitis

This medicine may cause severe pancreatitis which is a serious life-threatening reaction in some patients. Discontinue the medicine if pancreatitis is detected. Report any signs and symptoms such as nausea, vomiting, or acute abdominal pain, etc. to the doctor immediately. Replacement with a suitable alternative may be required based on the clinical condition.

Bleeding disorder

Use with caution in patients with the bleeding disorder as it may cause Thrombocytopenia. Make necessary dosage adjustments or discontinue the medicine if this condition is identified.

Impaired kidney function

This medicine should be used with caution in patients with kidney diseases due to the increased risk of worsening of the patient's condition. Close monitoring of kidney function is recommended during treatment with this medicine. Appropriate dose adjustments or replacement with a suitable alternative may be required based on the clinical condition of the patient.

Suicidal ideation

This medicine may increase the risk of suicidal thoughts. Appropriate dose adjustments should be done in patients with depression or suicidal tendencies.

Systemic lupus erythematosus

This medicine should be used with caution in patients with Systemic lupus erythematosus due to the risk of worsening of the patient's condition. Appropriate dose adjustments or replacement with a suitable alternative may be required based on the clinical condition of the patient.

Weight gain

Therapy with this medicine may cause weight gain in some patients.

Driving and operating machinery

This medicine may cause symptoms such as weakness, drowsiness, sleepiness, dizziness, etc. in some patients. It is advised that you do not perform any activities such as driving a vehicle or operating heavy machinery if you experience any of these symptoms during treatment with this medicine.

Other uses

Your doctor may prescribe this medicine to treat manic episodes (a mental disorder characterized by hyperactivity and racing thoughts) associated with bipolar disorder and sometimes may be used as prophylaxis in migraine headaches characterized by severe headache, eye pain, nausea, and vomiting in certain circumstances.

Missed Dose

Take the missed dose as soon as you remember. If it is almost the time for your next dose, skip the missed dose. Do not double your dose to make up for the missed dose.

Overdose

Seek emergency medical treatment or contact the doctor in case of an overdose.
All drugs interact differently for person to person. You should check all the possible interactions with your doctor before starting any medicine.
Interaction with Alcohol

Description

N/A

Instructions

Consumption of alcohol is not recommended during treatment with this medicine due to the increased risk of side effects such as dizziness, difficulty in concentration, drowsiness, etc. It is advised that you do not perform any activities that require high mental alertness such as driving a vehicle or operating machinery if you consume alcohol during treatment with this medicine.
Interaction with Medicine

Lamotrigine

Metoclopramide

Warfarin

Ethinyl Estradiol

Imipenem

Zidovudine

Disease interactions

Depression

This medicine should be used with caution in patients with depression and suicidal thoughts. Frequent monitoring of depression symptoms is necessary. Appropriate dose adjustments or replacement with a suitable alternative may be required based on the clinical condition. Do not stop the use of any medicine without consulting your doctor.

Liver Disease

This medicine should be used with extreme caution in patients with liver diseases due to the risk of worsening of the condition. Liver function tests are to be performed before starting the treatment with this medicine. Discontinue the medicine if any abnormality is identified. It is not recommended for use in patients with active and/or severe liver diseases.
Food interactions
Information not available.
Lab interactions

Thyroid function tests

This medicine may alter thyroid function test results. It is advised to inform the doctor and the laboratory technicians about the use of this medicine before undergoing any laboratory tests.

Urine ketone test

This medicine may lead to a false interpretation of the urine ketone test. It is advised to inform the doctor and the laboratory technicians about the use of this medicine before undergoing any laboratory tests.
Take this medicine exactly as prescribed by the doctor. Do not take in larger or smaller quantities than recommended. Consult the doctor if you experience any undesirable side effects. Ensure that the treatment course is completed. Do not stop the use of this medicine without consulting your doctor.
Miscelleneous

Can be taken with or without food, as advised by your doctor

To be taken as instructed by doctor

May cause sleepiness

How it works
This medicine works by works by binding to the receptors in the brain and inhibits the excitation of brain cells.
Legal Status

Approved

Unknown

Unknown

Unknown

Classification

Category

Anticonvulsants Agents

Schedule

Schedule H

[Internet]. Emenoxhealthcare.com. 2019 [cited 12 December 2019]. Available from:

http://www.emenoxhealthcare.com/noxval-chrono/

Valproic Acid: MedlinePlus Drug Information [Internet]. Medlineplus.gov. 2017 [cited 9 April 2017]. Available from:

https://medlineplus.gov/druginfo/meds/a682412.html

DailyMed - valproate sodium injection [Internet]. Dailymed.nlm.nih.gov. 2017 [cited 9 April 2017]. Available from:

https://dailymed.nlm.nih.gov/dailymed/drugInfo.cfm?setid=7a687b2f-246d-4736-a20c-92421c263268#section-8.1
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Information on this page was last updated on 8 Jan 2020

Disclaimer

We’ve made all possible efforts to ensure that the information provided here is accurate, up-to-date and complete, however, it should not be treated as a substitute for professional medical advice, diagnosis or treatment. Practo only provides reference source for common information on medicines and does not guarantee its accuracy or exhaustiveness. The absence of a warning for any drug or combination thereof, should not be assumed to indicate that the drug or combination is safe, effective, or appropriate for any given patient. Practo does not assume any responsibility for any aspect of healthcare administered with the aid of information provided above. If you have any doubts about your medication then we strongly recommend that you consult with your doctor, nurse or healthcare provider. See detailed T&C here.