Gardcef 750 Injection

Manufactured byIPCA LABORATORIES PVT LTD
ContainsCeftazidime (500 mg) + Sulbactam (250 mg)
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Valid on prescription medicines, only for first time user
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Description

Gardcef 750 Injection is a combination medicine used to treat infections of the brain, lungs, skin, blood, urinary tract, abdomen, bones, joints, etc. caused by bacteria. This medicine should be used with caution in patients with kidney diseases due to the increased risk of severe adverse effects.

Substitutes

List of substitutes for Gardcef 750 Injection

Side effects

Major & minor side effects for Gardcef 750 Injection

  • Diarrhea
  • Nausea and Vomiting
  • Itching
  • Fatigue
  • Chills
  • Swelling
  • Abdominal pain
  • Bloating
  • Fever
  • Swelling and redness at the injection site
  • White patches in the mouth or on the tongue
  • Dizziness
  • Fast heartbeat
  • Headache
  • Skin rash
  • Yellow colored eyes or skin

Uses of Gardcef 750 Injection

What is it prescribed for?

  • Lower Respiratory Tract Infection
  • Central nervous system infections
  • Bacterial Septicemia
  • Intra-abdominal Infections
  • Skin and Skin Structure Infection
  • Bone and joint infections
  • Urinary tract infection
  • Gynecologic infections
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Concerns

Commonly asked questions

  • Onset of action
    The effect of this medicine occurs rapidly after an intravenous administration. The peak effect of this medicine can be observed within 1 hour after an intramuscular administration.
  • Duration of effect
    The amount of time for which this medicine remains active in the body is not clinically established.
  • Safe with alcohol?
    Interaction with alcohol is unknown. It is advisable to consult your doctor before consumption.
  • Is it habit forming?
    No habit-forming tendencies were reported.
  • Usage in pregnancy?
    This medicine is not recommended for use in pregnant women unless absolutely necessary. All the risks and benefits should be discussed with the doctor before taking this medicine.
  • Usage while breast-feeding?
    This medicine is not recommended for use in breastfeeding women unless absolutely necessary. All the risks and benefits should be discussed with the doctor before receiving this medicine. If the medicine is used, monitor the infant closely for any undesired side effects.

Allergy

This medicine is not recommended for use in patients with a known allergy to ceftazidime, sulbactam, beta-lactam antibiotics, or any other inactive ingredients present along with these medicines.
Warnings for special population

Pregnancy

This medicine is not recommended for use in pregnant women unless absolutely necessary. All the risks and benefits should be discussed with the doctor before taking this medicine.

Breast-feeding

This medicine is not recommended for use in breastfeeding women unless absolutely necessary. All the risks and benefits should be discussed with the doctor before receiving this medicine. If the medicine is used, monitor the infant closely for any undesired side effects.
General warnings

Electrolyte imbalance

This medicine should be used with caution in patients with a known history of electrolyte imbalance since it may worsen the patient's condition. Report any unusual symptoms to the doctor immediately. Close monitoring of electrolyte levels, appropriate dose adjustments, or replacement with a suitable alternative may be required based on the clinical condition of the patient.

Epilepsy

This medicine should be used with caution in patients with a known history of epilepsy due to the increased risk of worsening of the patient's condition. Report any unusual symptoms to the doctor immediately. Appropriate dose adjustments or replacement with a suitable alternative may be required based on the clinical condition of the patient.

Hypersensitivity reactions

This medicine may cause serious and occasionally fatal hypersensitivity reactions including anaphylactic shock in some patients. This risk is especially high in patients with a history of sensitivity to multiple allergens. If an anaphylactic reaction occurs, the treatment should be discontinued immediately and appropriate corrective measures should be undertaken.

Drug-resistance

Usage of this medicine without sufficient proof or suspicion of a bacterial infection should be avoided. Irrational dosing might fail in providing the benefits and even cause toxicity. It may also increase the risk of development of bacteria that are drug resistant.

Clostridium difficile-associated Diarrhea

Discontinue the use of this medicine as per the doctor's instructions if severe diarrhea occurs after receiving this medicine. This medicine may cause an imbalance in the microbial flora of the large intestine, decreasing the gut-friendly bacteria and promoting the growth of a bacteria called Clostridium difficile, resulting in severe diarrhea.

Neurotoxicity

This medicine may increase the risk of serious adverse effects such as encephalopathy, seizures, and nonconvulsive status epilepticus. These reactions may occur in patients with an impaired kidney function if the dose of this medicine is not adjusted appropriately. Appropriate dose adjustments or replacement with a suitable alternative may be required based on the clinical condition of the patient.

Missed Dose

Since this medicine is administered by a qualified healthcare professional in the clinical or hospital setting, the likelihood of a missed dose is very low.

Overdose

Since this medicine is administered in the hospital or clinical setting by a qualified healthcare professional, the likelihood of an overdose is very low. However, emergency medical treatment will be initiated by the doctor if an overdose is suspected.
All drugs interact differently for person to person. You should check all the possible interactions with your doctor before starting any medicine.
Interaction with Alcohol

Description

Interaction with alcohol is unknown. It is advisable to consult your doctor before consumption.

Instructions

Interaction with alcohol is unknown. It is advisable to consult your doctor before consumption.
Interaction with Medicine

Amikacin

Ethinyl Estradiol

Cholera Vaccine

Furosemide

Cyclosporine

Probenecid

Disease interactions

Renal impairment

This medicine should be used with extreme caution in patients with a known history of renal diseases due to the increased risk of severe adverse effects. Close monitoring of kidney function, appropriate dose adjustments, or replacement with a suitable alternative may be required in some cases based on the clinical condition of the patient.

Gastrointestinal Disorders

This medicine should be used with extreme caution in patients having a history of gastrointestinal diseases, particularly colitis, since it may worsen the patient's condition. Report any incidence of severe diarrhea, abdominal pain, blood in stools, etc. to the doctor immediately. Appropriate dose adjustments or replacement with a suitable alternative may be required based on the clinical condition of the patient.

Seizure disorders

This medicine should be used with extreme caution in patients with a history of seizure disorder and other central nervous system abnormalities since it may worsen the patient's condition. Report any incidence of tremors, restlessness, anxiety, confusion, hallucinations, etc., to the doctor on priority. Appropriate dose adjustments or replacement with a suitable alternative may be necessary based on the clinical condition of the patient.
Food interactions
Information not available.
Lab interactions
Information not available.
This medicine should be administered by a qualified healthcare professional in the clinical or hospital setting. Inform the doctor if you have a known history of allergy to this medicine. Report to the doctor all your current medicines as well as your medical conditions before receiving this medicine. Report any undesirable side effects to the doctor promptly.
Miscelleneous

Usage does not depend on food timings

To be taken as instructed by doctor

May cause sleepiness

How it works
Ceftazidime works by stopping the growth of bacteria. Sulbactam inhibits some chemicals produced by the bacteria and makes the bacteria more sensitive to ceftazidime activity. Thus, the combination becomes effective against an extended range of bacteria.
Legal Status

Approved

Unknown

Unknown

Unknown

Classification

Category

Third generation cephalosporins, Beta-lactamase inhibitors

Schedule

Schedule H

Ceftazidime Injection: MedlinePlus Drug Information [Internet]. Medlineplus.gov. 2017 [cited 31 March 2017]. Available from:

https://medlineplus.gov/druginfo/meds/a686007.html

DailyMed - Ceftazidime injection, powder, for solution [Internet]. Dailymed.nlm.nih.gov. 2017 [cited 31 March 2017]. Available from:

https://dailymed.nlm.nih.gov/dailymed/drugInfo.cfm?setid=112c5457-8d71-49f5-b531-9761d7d38c93#s37

Sulbactam - DrugBank [Internet]. Drugbank.ca. 2018 [cited 19 March 2018]. Available from:

https://www.drugbank.ca/drugs/DB09324

Sulbactam [Internet]. Pubchem.ncbi.nlm.nih.gov. 2018 [cited 19 March 2018]. Available from:

https://pubchem.ncbi.nlm.nih.gov/compound/sulbactam#section=Top

[Internet]. CiplaMed. 2018 [cited 19 March 2018]. Available from:

https://ciplamed.com/content/sulbacip-iv-injection
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