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Epineuron Tablet

Manufactured byARISTO PHARMACEUTICALS PVT LTD
ContainsEpalrestat (50 mg) + Methylcobalamin (500 mcg)
Description

Epineuron Tablet is used for the treatment of diabetic peripheral neuropathy, one of the most common long-term complications in patients suffering from diabetes mellitus.

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Side effects

Major & minor side effects for Epineuron Tablet

  • Nausea and vomiting
  • Diarrhea
  • Dizziness
  • Irregular heartbeat
  • Abdominal pain
  • Dry mouth
  • Weakness and general discomfort
  • Headache
  • Skin rash

Uses of Epineuron Tablet

What is it prescribed for?

  • Diabetic Peripheral Neuropathy
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Concerns

Commonly asked questions

  • How long does it take for this medicine to take effect?
    The amount of time required for this medicine to show its action is not clinically established.
  • How long do the effects of this medicine last?
    The amount of time for which this medicine remains active in the body is not clinically established.
  • Is it safe to consume alcohol while taking this medicine?
    Consumption of alcohol is not recommended during treatment with this medicine due to the increased risk of serious adverse effects such as drowsiness, confusion, impaired judgment, etc. It is advised that you do not perform any activities such as driving a vehicle or operating heavy machinery if you consume alcohol during treatment with this medicine.
  • Is this a habit forming medicine?
    No habit-forming tendencies were reported.
  • Can this medicine be taken during pregnancy?
    This medicine is not recommended for use in pregnant women unless absolutely necessary. All the risks and benefits should be discussed with the doctor before taking this medicine. Your doctor may prescribe a safer alternative based on your clinical condition.
  • Can this medicine be taken while breast-feeding?
    This medicine is not recommended for use in breastfeeding women unless absolutely necessary. All the risks and benefits should be discussed with the doctor before taking this medicine. If the medicine is used, the infant should be monitored closely for any undesired side effects. Alternatively, your doctor may prescribe a safer alternative based on your clinical condition.

Leber's Disease

This medicine is not recommended for use in patients who have Leber's Disease, a rare genetic disorder.

Allergy

This medicine is not recommended for use in patients with a known allergy to epalrestat, methylcobalamin, or any other inactive ingredients present along with the formulation.
Warnings for special population

Pregnancy

This medicine is not recommended for use in pregnant women unless absolutely necessary. All the risks and benefits should be discussed with the doctor before taking this medicine. Your doctor may prescribe a safer alternative based on your clinical condition.

Breast-feeding

This medicine is not recommended for use in breastfeeding women unless absolutely necessary. All the risks and benefits should be discussed with the doctor before taking this medicine. If the medicine is used, the infant should be monitored closely for any undesired side effects. Alternatively, your doctor may prescribe a safer alternative based on your clinical condition.
General warnings

Elderly patients

This medicine should be used with caution in elderly patients due to the increased risk of severe adverse effects. Close monitoring of the clinical condition, appropriate dose adjustments, or replacement with a suitable alternative may be necessary based on the clinical condition of the patient.

Other medicines

This medicine may interact with many other medicines and may cause severe adverse effects. Hence, it is advised that you inform the doctor about all your current medicines including any herbs and supplements before beginning treatment with this medicine.

Gastrointestinal surgery

This medicine should be used with caution in patients who have had a recent gastrointestinal surgery due to the chances of decreased absorption of this medicine. Appropriate dose adjustments or replacement with a suitable alternative may be required in some cases based on the clinical condition.

Liver impairment

This medicine should be used with caution in patients with liver diseases due to the increased risk of severe adverse effects. Close monitoring of liver function is recommended for such patients. Appropriate dose adjustments or replacement with a suitable alternative may be necessary based on the clinical condition.

Use of antacids

Coadministration of antacids and this medicine may reduce the absorption of this medicine. Your doctor may suggest an appropriate time-gap between the administration of these medicines to minimize/avoid their interaction. Replacement with a suitable alternative may be required based on the clinical condition of the patient.

Driving or operating machines

This medicine may cause dizziness in some patients. It is advised that you do not perform any activities such as driving a vehicle or operating machinery if you experience dizziness during treatment with this medicine.

Kidney impairment

This medicine should be used with caution in patients with kidney diseases due to the increased risk of severe adverse effects. Close monitoring of kidney function is recommended for such patients. Appropriate dose adjustments or replacement with a suitable alternative may be necessary based on the clinical condition.

Use in children

This medicine is not recommended for use in children since the safety and efficacy of use are not clinically established.

Missed Dose

Take the missed dose as soon as you remember. If it is almost time for your next scheduled dose, skip the missed dose. Do not double your dose to make up for the missed one.

Overdose

Seek emergency medical treatment or contact the doctor in case of an overdose.
All drugs interact differently for person to person. You should check all the possible interactions with your doctor before starting any medicine.
Interaction with Alcohol

Description

N/A

Instructions

Consumption of alcohol is not recommended during treatment with this medicine due to the increased risk of serious adverse effects such as drowsiness, confusion, impaired judgment, etc. It is advised that you do not perform any activities such as driving a vehicle or operating heavy machinery if you consume alcohol during treatment with this medicine.
Interaction with Medicine

Chloramphenicol

Omeprazole

Ranitidine

Antidiabetic drugs

Disease interactions

Disease

Information not available.
Food interactions
Information not available.
Lab interactions
Information not available.
Take this medicine as instructed by your doctor. You are advised to take this medicine before food. Do not take in larger or smaller amounts than advised/prescribed. Consult the doctor if you experience any undesirable side effects. Do not stop the use of this medicine without consulting your doctor.
Miscelleneous

Can be taken with or without food, as advised by your doctor

To be taken as instructed by doctor

May cause sleepiness

How it works
Epalrestat reduces the levels of sorbitol which is responsible for damage to the nerves. Methylcobalamin works by facilitating the enzymes responsible for the production of vital components and energy inside a cell.
Legal Status

Approved

Unknown

Unknown

Unknown

Classification

Category

Aldose reductase inhibitor, Vitamins

Schedule

Schedule H

[Internet]. Pdfs.semanticscholar.org. 2019 [cited 15 January 2019]. Available from:

https://pdfs.semanticscholar.org/4759/1bb62346cee5cd9d69c40a67c68ca777ff1f.pdf

[Internet]. Pharmrev.aspetjournals.org. 2019 [cited 15 January 2019]. Available from:

http://pharmrev.aspetjournals.org/content/pharmrev/64/4/880.full.pdf

B12 V. Vitamin B12: MedlinePlus Medical Encyclopedia [Internet]. Medlineplus.gov. 2019 [cited 15 January 2019]. Available from:

https://medlineplus.gov/ency/article/002403.htm

Methylcobalamin hydrate | C63H93CoN13O15P - PubChem [Internet]. Pubchem.ncbi.nlm.nih.gov. 2019 [cited 15 January 2019]. Available from:

https://pubchem.ncbi.nlm.nih.gov/compound/91886214
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Information on this page was last updated on 12 Jul 2019

Disclaimer

We’ve made all possible efforts to ensure that the information provided here is accurate, up-to-date and complete, however, it should not be treated as a substitute for professional medical advice, diagnosis or treatment. Practo only provides reference source for common information on medicines and does not guarantee its accuracy or exhaustiveness. The absence of a warning for any drug or combination thereof, should not be assumed to indicate that the drug or combination is safe, effective, or appropriate for any given patient. Practo does not assume any responsibility for any aspect of healthcare administered with the aid of information provided above. If you have any doubts about your medication then we strongly recommend that you consult with your doctor, nurse or healthcare provider. See detailed T&C here.