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Clostop SR Tablet
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Clostop SR Tablet

Manufactured byAlembic Ltd.
ContainsMefenamic acid (250 mg) + Tranexamic Acid (500 mg)
Description
Clostop SR Tablet is a combination of Mefenamic acid and Tranexamic acid. It is used to treat pain and heavy bleeding during menstruation. It prevents the breakdown of blood clots, which helps to reduce heavy menstrual flow. It also blocks the production of specific chemical substances responsible for causing pain. Clostop SR Tablet shows side effects like nausea, vomiting, stomach pain, headache, heartburn (burning pain in your chest), diarrhoea, dizziness, muscle pain, and anaemia (low number of blood cells). Clostop SR Tablet can be taken with or without food. It is recommended that you take it after food to avoid an upset stomach. It must be consumed as a whole tablet without crushing or breaking it. Inform your doctor if you observe any abnormalities in your menstrual cycle. Clostop SR Tablet is effective when taken on the first day of your menstruation. Do not increase your dose or take it more frequently, or take it for a longer time than prescribed. Consult your doctor if your condition does not improve after two consecutive cycles. Clostop SR Tablet has to be used with caution if you have any kidney problems, a history of convulsion or if have/had a blood clot(s). Inform your doctor about all these conditions and also if you are pregnant or are breastfeeding.
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Side effectsConcernsUsage

Side effects

Major & minor side effects for Clostop SR Tablet

  • Diarrhoea
  • Bloating
  • Headache
  • Dizziness
  • Ringing or buzzing in the ears
  • Blurred vision
  • Weight gain
  • Shortness of breath
  • Swelling of face, lips, eyelids, tongue, hands and feet
  • Peeling and blistering of skin
  • Fast heartbeat
  • Unusual bleeding or bruising
  • Yellow coloured eyes or skin
  • Difficult or painful urination
  • Bloody and Cloudy urine
  • Excessive tiredness
  • Back pain
  • Nasal congestion
  • Nausea or Vomiting
  • Heartburn
  • Anemia

Uses of Clostop SR Tablet

What is it prescribed for?

  • Heavy menstrual bleeding
  • Menstrual pain
Read More
Concerns

Commonly asked questions

  • How long does it take for this medicine to take effect?
    The time at which Clostop SR Tablet starts to act is unknown. However, it may take 24 hours for the medicine to take full effect.
  • How long do the effects of this medicine last?
    It is no known how long Clostop SR Tablet remains active in your body.
  • Is it safe to consume alcohol while taking this medicine?
    Alcohol can increase the risk of side effects such as dizziness, drowsiness, confusion, difficulty in concentrating, and stomach bleeding when taken along with this medicine. It is recommended that you limit or avoid the consumption of alcohol during treatment with Clostop SR Tablet.
  • Is this a habit forming medicine?
    No habit-forming tendencies were reported with Clostop SR Tablet.
  • Can this medicine be taken during pregnancy?
    It is not recommended to take Clostop SR Tablet during pregnancy since it might cause abnormalities in your developing foetus. If you take this medicine, it may delay labour and increase the risk of bleeding. Consult your doctor before taking this medicine if you are pregnant.
  • Can this medicine be taken while breast-feeding?
    If you are breastfeeding, it is not recommended to take Clostop SR Tablet as there is no sufficient data available to see if this medicine passes into your breastmilk. Hence, consult your doctor before taking this medicine if you are breastfeeding.

Allergy

Avoid taking Clostop SR Tablet if you are allergic to it. Seek immediate medical attention if you notice any symptoms such as skin rash, itching/swelling (especially of the face/tongue/throat), severe dizziness, breathing difficulty, etc.

Asthma

Clostop SR Tablet can cause allergic reactions like constriction of your airways leading to breathing difficulty. If you have asthma, inform your doctor beforehand as this medicine can trigger asthma attacks.

Coronary Artery Bypass Surgery (CABG)

Coronary Artery Bypass Surgery (CABG) is a surgical technique that is used to restore normal blood flow to your heart. Clostop SR Tablet prevents blood clots from breaking, leading to obstruction in your normal blood flow. Hence, if you recently had bypass surgery, you should not take Clostop SR Tablet.

Subarachnoid haemorrhage

Subarachnoid haemorrhage is bleeding between your brain and the tissue that covers the brain. You should not take Clostop SR Tablet in such conditions as it prevents the breakdown of blood clots and can cause obstruction to the blood flow and blood thickening. Using this medicine in cases of subarachnoid haemorrhage is not advisable, as it can worsen your condition and lead to cerebral oedema (swelling of the brain) and infarction (obstruction of the blood supply to an organ).

Obstructive blood clotting disorder

Obstructive blood clotting disorder is an abnormal formation of blood clots because of certain problems like slow blood flow through your veins, an irregularity in clot formation components, and/or damage to the blood vessel wall. Clostop SR Tabletworks by preventing the breakdown of clots. Hence, it is not recommended for use if you have any clotting disorders as this can worsen your condition.
Warnings for special population

Pregnancy

It is not recommended to take Clostop SR Tablet during pregnancy since it might cause abnormalities in your developing foetus. If you take this medicine, it may delay labour and increase the risk of bleeding. Consult your doctor before taking this medicine if you are pregnant.

Breast-feeding

If you are breastfeeding, it is not recommended to take Clostop SR Tablet as there is no sufficient data available to see if this medicine passes into your breastmilk. Hence, consult your doctor before taking this medicine if you are breastfeeding.
General warnings

Peptic ulcer

Peptic ulcers are open sores that develop in your stomach when there is excess production of stomach acid. You should take Clostop SR Tablet with extreme caution if you are suffering from peptic ulcer disease as this medicine can increase the risk of severe stomach bleeding.

Allergic skin reactions

Clostop SR Tablet may cause serious skin allergies. If you notice any signs and symptoms like rashes, hives (itchy, painful eruptions that sting), or other allergic symptoms, report them immediately to your doctor. You may discontinue the treatment on your doctor’s recommendation.

Use of hormonal contraceptives

If you are taking any hormonal contraceptives (birth control) like pills, patches, vaginal rings, or injections, avoid taking Clostop SR Tablet. This medicine may increase the risk of serious side effects in such cases. The risk is more if you are overweight, smoke cigarettes, or are above the age of 35.

Eye disorders

If you have problems related to the eyes, take Clostop SR Tablet with caution as it can increase the risk of visual disturbances. You should get a regular eye test performed before starting the medication and also at regular intervals throughout the treatment.

Use in children

Clostop SR Tablet is not recommended for use in children less than 14 years of age.

Driving or operating machinery

You may experience blurred vision or dizziness after taking Clostop SR Tablet. Hence, it is advised not to drive vehicles and operate any machines after taking this medicine.

Missed Dose

Take the missed dose of Clostop SR Tablet as soon as you remember. If your next dose is near, skip the missed dose. Do not double your dose to compensate for a missed one.

Overdose

Never take more than the prescribed dose. Seek emergency medical treatment or contact your doctor in case of an overdose with Clostop SR Tablet.
All drugs interact differently for person to person. You should check all the possible interactions with your doctor before starting any medicine.
Interaction with Alcohol

Description

N/A

Instructions

Alcohol can increase the risk of side effects such as dizziness, drowsiness, confusion, difficulty in concentrating, and stomach bleeding when taken along with this medicine. It is recommended that you limit or avoid the consumption of alcohol during treatment with Clostop SR Tablet.
Interaction with Medicine

Ramipril

Methotrexate

Warfarin

Reteplase

Acalabrutinib

Tenecteplase

Carfilzomib

Urokinase

Alteplase

Disease interactions

Gastrointestinal Diseases

Long term use of Clostop SR Tablet can cause damage to your stomach and intestine leading to serious conditions like bleeding and ulceration in your stomach or intestinal wall. Inform your doctor if you experience any symptoms indicating ulceration and bleeding like chronic indigestion, the appearance of coffee coloured dry blood in stools, or vomiting of blood.

Impaired kidney function

Taking Clostop SR Tablet for a longer period of time may cause kidney problems, such as painful urination and blood in your urine. Hence, use this medicine cautiously if you have any kidney problems. Your doctor will suggest tests to monitor your kidney function while taking this medicine.

Impaired liver function

If you have any liver problems, consult your pharmacist/doctor about how Clostop SR Tablet may affect your liver. Using this medicine if you have pre-existing liver problems, can cause serious side effects leading to liver failure.

Epilepsy

Inform your doctor if you have epilepsy. It is also important to discuss with your doctor how Clostop SR Tablet will affect your condition.
Food interactions
Information not available.
Lab interactions
Information not available.
This is not an exhaustive list of possible drug interactions. You should consult your doctor about all the possible interactions of the drugs you’re taking.
Take Clostop SR Tablet as instructed by the doctor. Take it with food to avoid stomach irritation. Drink plenty of water to avoid dehydration. Do not take more or less than the prescribed dose, or for a longer duration than recommended. Follow the dose as directed by your doctor. This medicine is more beneficial if you take it on the first day of your period. Inform your doctor if your bleeding does not improve after using this medication for two consecutive cycles. If you experience any severe side effects, contact your doctor.
Miscelleneous

To be taken with food

To be taken as instructed by doctor

May cause sleepiness

How it works
Clostop SR Tablet is a combination medicine of Mefenamic acid and Tranexamic acid. Mefenamic acid is a non-steroidal anti inflammatory drug (NSAID) that provides relief from menstrual pain by blocking the release of a chemical called prostaglandins, which increases pain and swelling. Tranexamic acid is a Antifibrinolytic that prevents excessive bleeding episodes by stopping the breakdown of blood clots.
Legal Status

Approved

Unknown

Unknown

Unknown

Classification

Category

Analgesics, Antifibrinolytic agents

Schedule

Schedule H

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https://pubchem.ncbi.nlm.nih.gov/compound/Mefenamic-acid>

Drugs, H., 2021. Mefenamic Acid: MedlinePlus Drug Information. [online] Medlineplus.gov. Available at: < [Accessed 24 June 2021].

https://medlineplus.gov/druginfo/meds/a681028.html>

Drugs, H., 2021. Tranexamic Acid: MedlinePlus Drug Information. [online] Medlineplus.gov. Available at: < [Accessed 24 June 2021].

https://medlineplus.gov/druginfo/meds/a612021.html>

Medicines.org.uk. 2021. Boots Cyklo-f Heavy Period Relief 500 mg Tablets - Patient Information Leaflet (PIL) - (emc). [online] Available at: < [Accessed 27 July 2021].

https://www.medicines.org.uk/emc/product/8290/pil>

Medicines.org.uk. 2021. Mefenamic Acid 500 mg film-coated Tablets - Summary of Product Characteristics (SmPC) - (emc). [online] Available at: < [Accessed 27 July 2021].

https://www.medicines.org.uk/emc/product/12503/smpc>

Bai, D. and Chandrakalam, P. (n.d.). Efficacy of Mefenamic Acid and Tranexamic Acid in the Management of Dysfunctional Uterine Bleeding. [online] . Available at: [Accessed 30 Jul. 2021]. ‌

http://www.ijhrmlp.org/pdfs/177.pdf

nhs.uk. (2020). Tranexamic acid - Medicine - NHS. [online] Available at: ‌

https://www.nhs.uk/medicines/tranexamic-acid/.
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Information on this page was last updated on 11 Nov 2021

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