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Cardace H (12.5/10 mg) Tablet
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Cardace H (12.5/10 mg) Tablet

Manufactured bySanofi India Ltd.
ContainsHydrochlorothiazide (12.5 mg) + Ramipril (10 mg)
Description
Cardace H (12.5/10 mg) Tablet is a combination of Hydrochlorothiazide and Ramipril. This medicine is used for the treatment of high blood pressure. It works by relaxing your blood vessels, which helps your heart to pump blood easily and increases water excretion from your body, thus decreases high blood pressure. Therefore, this medicine also reduces the risk of heart attack and stroke. Cardace H (12.5/10 mg) Tablet has some side effects like cough, nausea, headache, dry mouth, and upset stomach. Due to the action of this medicine, you may experience frequent urination while taking this medicine, and it is not a side effect. Drink plenty of fluids while taking medicine to overcome muscle weakness, dry mouth, and extreme thirst. Cardace H (12.5/10 mg) Tablet may cause dizziness in some patients. Avoid driving vehicles or operating machines and rise slowly from a sitting or lying position if you feel dizzy while on Cardace H (12.5/10 mg) Tablet treatment. If any of these side effects do not resolve with time or get worse, seek a doctor's consultation at the earliest. Avoid taking this medicine if you are allergic to it. Cardace H (12.5/10 mg) Tablet should be taken with or without food, preferably in the morning to avoid frequent urination at night. Do not stop taking this medicine suddenly as it can cause your blood pressure to rise. This increases the risk of heart attack and stroke. Cardace H (12.5/10 mg) Tablet should be used with caution if you have kidney disease, liver disease, or diabetes. Let your doctor know if you are taking any other medicines before starting the treatment. Frequent monitoring of your heart, liver, kidney functions and electrolytes levels may be required to use this medicine safely. Cardace H (12.5/10 mg) Tablet is not recommended for use in children. Consult your doctor if you are pregnant, planning a pregnancy or are breastfeeding before using Cardace H (12.5/10 mg) Tablet.
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Side effectsConcernsUsageRelated products

Side effects

Major & minor side effects for Cardace H (12.5/10 mg) Tablet

  • Increased urination
  • Itching or rash
  • Abdominal and stomach pain
  • Dry mouth
  • Joint pain, stiffness, and swelling
  • Cramping
  • Blurred vision
  • Sweating
  • Dizziness
  • Unusual tiredness and weakness
  • Back pain
  • Chest tightness
  • Increased heartbeat
  • Cough
  • Diarrhoea
  • Nausea and Vomiting
  • Decreased blood pressure

Uses of Cardace H (12.5/10 mg) Tablet

What is it prescribed for?

  • Hypertension
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Concerns

Commonly asked questions

  • How long does it take for this medicine to take effect?
    The effect of Cardace H (12.5/10 mg) Tablet can be observed within 2 hours of taking the dose.
  • How long do the effects of this medicine last?
    The effect of Cardace H (12.5/10 mg) Tablet lasts for an average duration of 24 hours.
  • Is it safe to consume alcohol while taking this medicine?
    Consumption of alcohol is not recommended during treatment with Cardace H (12.5/10 mg) Tablet due to the increased risk of side effects. Avoid performing any activities that require high mental alertness such as driving vehicles or operating machines.
  • Is this a habit forming medicine?
    Cardace H (12.5/10 mg) Tablet has no habit forming tendency.
  • Can this medicine be taken during pregnancy?
    Cardace H (12.5/10 mg) Tablet is not recommended during pregnancy. Consult your doctor if you are pregnant before taking this medicine.
  • Can this medicine be taken while breast-feeding?
    Cardace H (12.5/10 mg) Tablet may pass into the breastmilk. Hence, consult your doctor if you are breastfeeding.

Allergy

It is recommended to avoid Cardace H (12.5/10 mg) Tablet if you are allergic to this medicine. Seek medical attention if you see symptoms such as skin rash, swelling (face, lips, tongue, etc.), breathing difficulty, etc.

Anuria

Taking Cardace H (12.5/10 mg) Tablet in case of anuria (a condition where the kidney is unable to produce urine) is not recommended as it may cause kidney damage.

Renal artery stenosis

Renal artery stenosis is a condition in which the blood vessels that carry blood to your kidneys become narrow and restrict blood flow. Cardace H (12.5/10 mg) Tablet is not recommended if you have renal artery stenosis as it reduces the filtration capacity that affects your kidneys.

Aliskiren

Combined use of Cardace H (12.5/10 mg) Tablet together with Aliskiren (a medicine used for reducing blood pressure) is not recommended if you have diabetes and/or kidney impairment with CrCl less than 60 ml/min. Combined use of these medicines may increase the risk of side effects.

Angioedema

Use of Cardace H (12.5/10 mg) Tablet is not recommended if you have a history of angioedema (swelling in the lower layer of your skin). In such cases, you may be at an increased risk of angioedema while receiving the treatment. Consult with your doctor if you have any concerns.
Warnings for special population

Pregnancy

Cardace H (12.5/10 mg) Tablet is not recommended during pregnancy. Consult your doctor if you are pregnant before taking this medicine.

Breast-feeding

Cardace H (12.5/10 mg) Tablet may pass into the breastmilk. Hence, consult your doctor if you are breastfeeding.
General warnings

Liver disease

Cardace H (12.5/10 mg) Tablet should be used with extreme caution if you have liver disease due to an increase in the risk of side effects. Close monitoring of liver function is necessary while taking this medicine. Report any symptoms of confusion or jaundice [yellow skin discolouration due to increased level of bilirubin (blood pigment)] to your doctor on priority.

Volume and electrolyte depletion

Cardace H (12.5/10 mg) Tablet may alter the blood volume and electrolyte levels in some patients. This may cause dizziness, dry mouth, and acid-base imbalance. This risk is especially higher if you have kidney and liver diseases. Close monitoring of blood pressure and electrolyte levels is recommended.

Kidney disease

Cardace H (12.5/10 mg) Tablet may cause Azotemia (elevated levels of urea and other nitrogen compounds in the blood) if you have a history of severe kidney disease. Your doctor will closely monitor your kidney function or adjust the dose to use this medicine safely.

Hyperkalemia

Cardace H (12.5/10 mg) Tablet may increase the potassium levels in the blood (hyperkalemia). It should be used with caution in patients with hyperkalemia and potassium levels should be monitored regularly. Avoid potassium-rich foods (potatoes, bananas) and potassium supplements during treatment with this medicine.

Use in children

Cardace H (12.5/10 mg) Tablet is not recommended for use in children and adolescents below 18 years of age because the safety and efficacy of this medicine are not clinically established.

Cough

Cardace H (12.5/10 mg) Tablet may cause a persistent nonproductive cough. It is resolved when the medicine is discontinued.

Driving and operating machines

Cardace H (12.5/10 mg) Tablet may cause dizziness and a decrease in blood pressure. Avoid performing any activity that requires high mental alertness like driving vehicles or operating machines.

Hypotension

Symptomatic hypotension (low blood pressure) may occur in patients with volume depletion (excess loss of salt and fluid leading to reduced fluid volume) or patients who are treated with high-dose diuretics (medication that increases the removal of water and salt from the body via urine). Correct this condition before initiating treatment with Cardace H (12.5/10 mg) Tablet.

Missed Dose

If you missed a dose of Cardace H (12.5/10 mg) Tablet, take it as soon as you remember. If it is time for the next dose, skip the missed dose. Take your next dose at your usual time. Do not double the dose.

Overdose

If you suspect that you might have taken an overdose of Cardace H (12.5/10 mg) Tablet, go to the emergency department of your local hospital.
All drugs interact differently for person to person. You should check all the possible interactions with your doctor before starting any medicine.
Interaction with Alcohol

Description

N/A

Instructions

Consumption of alcohol is not recommended during treatment with Cardace H (12.5/10 mg) Tablet due to the increased risk of side effects. Avoid performing any activities that require high mental alertness such as driving vehicles or operating machines.
Interaction with Medicine

Losartan

Corticosteroids

Insulin

Nonsteroidal anti-inflammatory medicines

Amitriptyline

Disease interactions

Diabetes

Cardace H (12.5/10 mg) Tablet should be used with caution in patients with Diabetes mellitus due to the increased risk of altered blood glucose levels.

Hyperuricemia

Cardace H (12.5/10 mg) Tablet should be used with caution in patients with hyperuricemia (increased uric acid levels in the blood). This medicine decreases uric acid excretion and increases uric acid in your blood.
Food interactions
Information not available.
Lab interactions
Information not available.
This is not an exhaustive list of possible drug interactions. You should consult your doctor about all the possible interactions of the drugs you’re taking.
Take Cardace H (12.5/10 mg) Tablet exactly as advised by your doctor. Drink plenty of water and electrolytes to avoid dehydration. Take Cardace H (12.5/10 mg) Tablet around the same time every day so that it is easy to remember. Try taking this medicine during the daytime to avoid frequent urination at night. It is given for the long term therefore do not stop taking this medicine without consulting your doctor. To get maximum benefits from the treatment, you should also adopt lifestyle changes like eating a low sodium and low-fat diet, exercising regularly, quit smoking, etc. Avoid potassium-rich foods like bananas, oranges etc. while taking Cardace H (12.5/10 mg) Tablet. Monitoring of kidney function and electrolytes levels is necessary while taking Cardace H (12.5/10 mg) Tablet. This medicine can cause dizziness so be careful while standing up from a sitting position. Do not break, crush or chew the tablet in your mouth.
Miscelleneous

Can be taken with or without food, as advised by your doctor

To be taken in morning

May cause sleepiness

How it works
Cardace H (12.5/10 mg) Tablet is a combination of Hydrochlorothiazide and Ramipril. Together these medicines effectively lower blood pressure and reduce the risk of heart diseases. Hydrochlorothiazide increases the excretion of water and sodium through the urine. Ramipril relaxes the blood vessels and promotes the smooth flow of blood.
Legal Status

Approved

Unknown

Unknown

Unknown

Classification

Category

Angiotensin converting enzyme inhibitors, Thiazide diuretics, ACE inhibitors with thiazides, Antihypertensive combinations

Schedule

Schedule H

Products.sanofi.in. 2021. [online] Available at: < [Accessed 31 August 2021].

http://products.sanofi.in/Cardace-H.pdf>

Accessdata.fda.gov. 2021. [online] Available at: < [Accessed 17 August 2021].

https://www.accessdata.fda.gov/drugsatfda_docs/label/2011/040735s004,040770s003lbl.pdf>

Medicines.org.uk. 2021. Ramipril 10mg Tablets - Summary of Product Characteristics (SmPC) - (emc). [online] Available at: < [Accessed 31 August 2021].

https://www.medicines.org.uk/emc/product/5902/smpc>

Dailymed.nlm.nih.gov. 2021. DailyMed - hydrochlorothiazide- Hydrochlorothiazide tablet. [online] Available at: < [Accessed 17 August 2021].

https://dailymed.nlm.nih.gov/dailymed/drugInfo.cfm?setid=7b38ac8a-4540-4eb2-aedd-9aa966d22190>

Dailymed.nlm.nih.gov. 2021. DailyMed - ramipril- Ramipril capsule. [online] Available at: < [Accessed 17 August 2021].

https://dailymed.nlm.nih.gov/dailymed/drugInfo.cfm?setid=8b59207a-ea5c-4697-a8b6-94c3015a00de>
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Information on this page was last updated on 7 Sep 2021

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