Amisulpride
Description
Amisulpride is an atypical anti-psychotic medicine that is used to treat symptoms like hallucinations, delusions, thought disturbances, lack of interest, apathy etc. that may be associated with mental disorders like psychoses and schizophrenia (acute and chronic).
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Side effects
Major & minor side effects for Amisulpride
- Fever
- Excessive sweating
- Change in heart rate
- Severe chest pain
- Swelling, pain, and redness in the legs
- Increased frequency of infections
- Severe skin allergy
- Seizures
- Restless legs
- Twitches in the tongue and face
- Trembling
- Excessive salivation
- Constipation
- Decreased libido
- Weight gain
- Amenorrhea
- Gynacomastia
- Agitation and anxiety
Uses of Amisulpride
What is it prescribed for?
- Acute psychosis
- Schizophrenia
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Concerns
Commonly asked questions
- Onset of actionThe time taken for the effect of this medicine to show may vary depending upon the symptoms. Some symptoms might show improvement within a day of consumption while other symptoms might take weeks.
- Duration of effectThe effect of this medicine is cumulative and lasts for a long duration of time.
- Safe with alcohol?Avoid or limit the uptake of alcohol while taking this medicine as the risk of adverse effects are increasingly high. Contact your doctor if an excess of drowsiness is experienced.
- Is it habit forming?This medicine has a moderate potential for abuse and habit forming tendencies were reported in a few cases.
- Usage in pregnancy?Use of this medicine during pregnancy is not recommended unless absolutely necessary. It is advised to use this medicine only when the benefits outweigh the risks involved.
- Usage while breast-feeding?Use of this medicine by breastfeeding women is not recommended. However, if it is absolutely necessary to use this medicine, then breastfeeding should be discontinued. Consult your doctor before using this medicine.
Allergy
This medicine is not recommended for use in patients having a known history of allergy to Amisulpride.
Pheochromocytoma
This medicine is not recommended for use in patients having a tumor of the adrenal glands that causes a life threatening rise in blood pressure.
Prolactin dependent tumor
This medicine is not recommended for use in patients having breast cancer which is associated with high levels of hormone prolactin in the body.
Levodopa
This medicine is not recommended for use in patients who are consuming levodopa as the effects of these medicines are exactly opposite.
Warnings for special population
Pregnancy
Use of this medicine during pregnancy is not recommended unless absolutely necessary. It is advised to use this medicine only when the benefits outweigh the risks involved.
Breast-feeding
Use of this medicine by breastfeeding women is not recommended. However, if it is absolutely necessary to use this medicine, then breastfeeding should be discontinued. Consult your doctor before using this medicine.
General warnings
Heart disease
This medicine should be used with caution in patients having a history of stroke, blood clotting disorders or other ailments of the heart and blood vessels.
Diabetes
This medicine should be used with caution in patients who are suffering from diabetes or are exposed to the risk factors.
Hypokalemia
This medicine should be used with caution in patients having low potassium levels in the body. It is recommended to initiate treatment with Amisulpride only after the potassium deficit is corrected.
Use in elderly
This medicine should be used with caution in the elderly as the risk of severe adverse effects are significantly higher.
Use in children
This medicine should not be used in children who have not attained puberty as the risk of adverse effects like hormonal imbalance and growth abnormalities are high.
Breast cancer
This medicine is not recommended for use if the patient is suspected to have breast cancer associated with abnormally high levels of prolactin in the body.
Leukopenia
This medicine is not recommended for use in patients who have a decreased white blood cell count characterized by frequent infections, fever with chills, sore throat, and mouth ulcers.
Suicide ideation
This medicine has been associated with suicide ideation in some patients. The patient should be properly counseled regarding this and any change in behavior indicating suicidal tendencies should be reported to the doctor.
Increase in prolactin levels
This medicine is known to cause an increase in the levels of the hormone prolactin in patients.
Drowsiness
This medicine is known to cause moderate to severe drowsiness and may the ability to perform tasks that require a high level of mental alertness. It is advised to refrain from driving or operating any heavy machinery after consuming this medicine.
Missed Dose
Take the missed dose as soon as you remember. However, if it is almost time for the next scheduled dose, then the missed dose should be skipped.
Overdose
Contact a doctor if an overdose with Amisulpride is suspected. Symptoms of an overdose may include excessive drowsiness, fall in blood pressure, agitation, coma etc.
All drugs interact differently for person to person. You should check all the possible interactions with your doctor before starting any medicine.
Interaction with Alcohol
Description
Consumption of alcohol while taking this medicine can cause CNS depression characterized by confusion, lack of focus, anxiety, drowsiness etc.
Instructions
Avoid or limit the uptake of alcohol while taking this medicine as the risk of adverse effects are increasingly high. Contact your doctor if an excess of drowsiness is experienced.
Interaction with Medicine
Diltiazem
Pregabalin
Tramadol
Amiodarone
Quinidine
Bromocriptine
Ropinirole
Disease interactions
Kidney Disease
This medicine should be used with caution in patients having an impaired kidney function. The impairment could be because of a disease or another medication that the patient is consuming. Suitable dose adjustment and clinical monitoring of safety are recommended in such cases.
Parkinson's disease
Use of this medicine is not recommended if the patient is suffering from Parkinson's disease. Consumption of this medicine will worsen the symptoms of the disease. Your doctor may prescribe an alternate medication under such circumstances.
Heart rhythm disorders
This medicine should be used with caution in patients who are either suffering from heart rhythm disorders or are suspected of having the condition. The risk of adverse effects are increasingly high in such cases and hence caution is advised.
Neuroleptic Malignant Syndrome (NMS)
Use of this medicine is not recommended if the patient suffers from Neuroleptic malignant syndrome. Introduction or reintroduction of this medicine should be done with caution in patients having a known history of this syndrome.
Food interactions
Information not available.
Lab interactions
Prolactin test
Report the use of this medicine before undergoing a laboratory test to determine the levels of the hormone prolactin in the body. This medicine can interfere with the test and yield false positive results.
Take Amisulpride as instructed by the doctor. This medicine should be taken at least an hour before food. It is advised to consume plenty of water while taking this medicine. The dose is likely to change over time based on individual response. It is advised to continue taking this medicine for the recommended duration even when the symptoms get better.
Miscelleneous
How it works
This medicine works by inhibiting the action of certain specific neurotransmitters in the brain.
Legal Status
Classification
Category
Atypical antipsychotics
Schedule
Schedule H
(plusmn)-amisulpride | C17H27N3O4S - PubChem [Internet]. Pubchem.ncbi.nlm.nih.gov. 2017 [cited 13 April 2017]. Available from:
amisulpride: Indication, Dosage, Side Effect, Precaution | CIMS India [Internet]. Mims.com. 2017 [cited 13 April 2017]. Available from:
[Internet]. 2017 [cited 13 April 2017]. Available from:
[Internet]. 2017 [cited 13 April 2017]. Available from:
Information on this page was last updated on 18 Apr 2017
Disclaimer
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