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Acord-Plus Tablet
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Acord-Plus Tablet

Manufactured byInvision Medi Sciences
ContainsLosartan (50 mg) + Atenolol (50 mg) + Hydrochlorothiazide (12.5 mg)
Description
Acord-Plus Tablet is a combination medicine used for the treatment of high blood pressure and relieving chest pain caused due to the reduced blood flow to the heart. Frequent monitoring of blood pressure and electrolytes level is necessary during treatment with this medicine. Patients are advised to maintain a strict diet and exercise regimen along with this medicine for the best possible effect.
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Side effectsConcernsUsage

Side effects

Major & minor side effects for Acord-Plus Tablet

  • Chills
  • Difficulty or painful urination
  • Back pain
  • Dizziness
  • Weakness in arms, hands, legs or feet
  • Nasal congestion
  • Sore throat
  • Drowsiness
  • Headache
  • Cough
  • Constipation
  • Diarrhea
  • Low blood pressure (hypotension)
  • Low blood sugar levels (hypoglycaemia)
  • Blurred vision
  • Difficulty in breathing
  • Sweating
  • Cold hands or feet
  • Increased thirst
  • Loss of appetite
  • Itching or rash
  • Dry mouth

Uses of Acord-Plus Tablet

What is it prescribed for?

  • Hypertension
  • Angina Pectoris
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Concerns

Commonly asked questions

  • How long does it take for this medicine to take effect?
    The effect of this medicine can be observed within 1 hour of administration of the dose.
  • How long do the effects of this medicine last?
    The effect of this medicine lasts for an average duration of 24 hours.
  • Is it safe to consume alcohol while taking this medicine?
    Consumption of alcohol is not recommended during treatment with this medicine due to the increased risk of side effects such as dizziness, lightheadedness, and fainting. It is advised that you do not perform any activities that require high mental alertness such as driving a vehicle or operating machinery if you consume alcohol during treatment with this medicine.
  • Is this a habit forming medicine?
    No habit-forming tendencies were reported.
  • Can this medicine be taken during pregnancy?
    This medicine is not recommended for use in pregnant women except in life-threatening conditions. All the risks and benefits should be discussed with the doctor before taking this medicine. Your doctor may prescribe a safer alternative based on your clinical condition.
  • Can this medicine be taken while breast-feeding?
    This medicine is not recommended for use in breastfeeding women unless absolutely necessary. All the risks and benefits should be discussed with the doctor before taking this medicine. Your doctor may advise you to discontinue breastfeeding or to discontinue the drug based on your clinical condition.

Allergy

This medicine is not recommended for use in patients with a known allergy to losartan, atenolol, hydrochlorothiazide, or any other inactive ingredients present in the formulation.

Aliskiren

Coadministration of aliskiren and this combination of medicine is not recommended due to the increased risk of serious adverse effects. This risk is especially higher in the elderly population and in patients with diabetes and kidney diseases.

Heart diseases

This medicine is not recommended for use in patients with heart diseases such as a heart block, sinus bradycardia, heart failure, cardiogenic shock, or sick sinus syndrome since it may worsen the patient's condition.

Severe pulmonary edema

This medicine is not recommended for use in patients with severe pulmonary edema due to the increased risk of worsening of the patient's condition.

Anuria

This medicine is not recommended for use in patients with anuria (a condition where the kidney is unable to produce urine) due to the increased risk of worsening of the patient's condition.
Warnings for special population

Pregnancy

This medicine is not recommended for use in pregnant women except in life-threatening conditions. All the risks and benefits should be discussed with the doctor before taking this medicine. Your doctor may prescribe a safer alternative based on your clinical condition.

Breast-feeding

This medicine is not recommended for use in breastfeeding women unless absolutely necessary. All the risks and benefits should be discussed with the doctor before taking this medicine. Your doctor may advise you to discontinue breastfeeding or to discontinue the drug based on your clinical condition.
General warnings

Hypotension

This medicine should be used with caution in patients who are sodium depleted and/or volume depleted by diuretic use since it may increase the risk of hypotension. The volume depleted and/or sodium depleted state should be corrected before starting the therapy or the treatment should be started at a lower dose. Vital signs should be monitored closely during therapy with this medicine.

Hyperkalemia

Use of this medicine may increase the potassium levels in the blood (hyperkalemia). This may cause serious side effects such as fatal cardiac rhythm irregularities. It is advised to avoid potassium-rich foods (potatoes, bananas) and other medicines that may increase potassium levels (ACE inhibitors and potassium supplements) during treatment with this medicine.

Liver Disease

This medicine should be used with caution in patients with liver diseases due to the increased risk of severe adverse effects. Close monitoring of liver function tests, appropriate dose adjustments, or replacement with a suitable alternative may be required based on the clinical condition.

Kidney Disease

This medicine should be used with caution in patients with kidney diseases due to the increased risk of worsening of the patient's condition. Close monitoring of kidney function is recommended for such patients. Appropriate dose adjustments or replacement with a suitable alternative may be required based on the clinical condition.

Driving or operating machinery

Use of this medicine may cause blurred vision or dizziness in some patients. It is advised that you do not perform any activities such as driving a vehicle or operating machinery if you experience any of these symptoms during treatment with this medicine.

Major surgery

This medicine should be used with caution in patients who are scheduled to undergo major surgery. An anesthetic agent with little negative inotropic activity should be selected to minimize the effect on the heart.

Lung Diseases

This medicine should be used with caution in patients with lung diseases who do not respond to other antihypertensive medications. Start with the lowest possible dose and increase the dose based on the clinical condition. Replacement with a suitable alternative may be required in some cases.

Hyperlipidemia

This medicine should be used with caution in patients with hyperlipidemia since it may alter the serum lipid profiles. Appropriate dose adjustments or replacement with a suitable alternative should be considered under your doctor's supervision.

Sports

Athletes are advised not to indulge in certain sports while using this medicine. Archery, racing, shooting and other high-risk sports should be avoided. Sportspersons should refer to the list of medicines published by World Anti-Doping Agency (WADA) which are not to be taken while participating in specific sports events.

Hyperthyroidism

This medicine should be administered with caution in patients with increased thyroid levels. Abrupt withdrawal of this medicine may lead to a life-threatening condition called thyroid-storm. Frequent monitoring of thyroid hormone levels is recommended for such patients. Appropriate dose adjustments or replacement with a suitable alternative may be required based on the clinical condition.

Volume and electrolyte depletion

Use of this medicine may alter the blood volume levels and electrolyte levels. This may cause dizziness, dry mouth, and acid-base imbalance. Close monitoring of blood pressure and electrolyte levels is necessary while taking this medicine. Report any symptoms such as weakness, lethargy, muscle pain, drowsiness, dizziness, irregular heartbeat, etc. to the doctor immediately.

Missed Dose

Take the missed dose as soon as you remember. If it is almost time for your next dose, skip the missed dose. Do not double your dose to make up for the missed one.

Overdose

Seek emergency medical treatment or contact the doctor in case of an overdose.
All drugs interact differently for person to person. You should check all the possible interactions with your doctor before starting any medicine.
Interaction with Alcohol

Description

N/A

Instructions

Consumption of alcohol is not recommended during treatment with this medicine due to the increased risk of side effects such as dizziness, lightheadedness, and fainting. It is advised that you do not perform any activities that require high mental alertness such as driving a vehicle or operating machinery if you consume alcohol during treatment with this medicine.
Interaction with Medicine

Alprazolam

Dexamethasone

Diltiazem

Captopril

Insulin

Theophylline

Nonsteroidal anti-inflammatory medicines

Benazepril

Perindopril

Disease interactions

Congestive heart failure

This medicine should be used with extreme caution in patients with congestive heart failure due to the increased risk of kidney impairment and worsening of the patient's condition. Close monitoring of heart function, blood pressure, and kidney function is recommended for such patients. Replacement with a suitable alternative may be required based on the clinical condition.

Asthma

This medicine is not recommended for use in patients with bronchial asthma or chronic obstructive pulmonary disease since it may worsen the patient's condition. Replacement with a suitable alternative should be done under your doctor's supervision.

Bradyarrhythmia/ AV Block

This medicine is not recommended for use in patients with Sinus Bradyarrhythmia or a heart block greater than the first degree due to the increased risk of worsening of the patient's condition. Replacement with a suitable alternative may be necessary based on the clinical condition.

Glaucoma

This medicine should be used with caution in patients with glaucoma because it may lower the intraocular pressure and worsen the patient's condition. Appropriate dose adjustments or replacement with a suitable alternative may be necessary based on the clinical condition.

Diabetes

This medicine should be used with caution in patients with a known history of diabetes mellitus due to the increased risk of altered blood glucose levels. Close monitoring of blood glucose levels is advised for such patients. Appropriate dose adjustments or replacement with a suitable alternative may be required based on the clinical condition.

Hyperuricemia

This medicine should be used with caution in patients with a history of gout or chronic renal failure due to the increased risk of hyperuricemia. Close monitoring of uric acid level is recommended for such patients. Appropriate dose adjustments or replacement with a suitable alternative may be necessary based on the clinical condition of the patient.
Food interactions
The desired effect of this medicine will not be achieved if taken together with multivitamin with minerals. You may need a dose adjustment or need to undergo special tests if these medicines are used together.
Avoid consumption of large amounts of orange juice with this medicine since it may decrease the effectiveness of the medicine.
It is advised to avoid potassium containing foods and supplements while taking this medicine due to the increased risk of weakness, confusion, irregular heartbeat, etc. Consult the doctor immediately in case of any unusual symptoms. Your dietitian/doctor may suggest appropriate changes in your diet based on your clinical condition.
Lab interactions
Information not available.
This is not an exhaustive list of possible drug interactions. You should consult your doctor about all the possible interactions of the drugs you’re taking.
Take this medicine exactly as advised by your doctor. Do not take in larger amounts than prescribed. Drink an adequate amount of water. Monitoring of kidney function and electrolytes levels is necessary while taking this medicine. Report any adverse effects to the doctor on priority. Do not stop the use of this medicine without consulting your doctor.
Miscelleneous

Can be taken with or without food, as advised by your doctor

To be taken as instructed by doctor

May cause sleepiness

How it works
Losartan and atenolol work by relaxing the blood vessels and promotes the smooth flow of blood. Hydrochlorothiazide increases the excretion of water and sodium through the urine. Their combination is thus effective in reducing blood pressure.
Legal Status

Unknown

Unknown

Unknown

Unknown

Classification

Category

Antihypertensive combinations, Angiotensin receptor blockers, Cardioselective beta blockers, Thiazide diuretics

Schedule

Schedule H

Hydrochlorothiazide - DrugBank [Internet]. Drugbank.ca. 2017 [cited 21 July 2017]. Available from:

https://www.drugbank.ca/drugs/DB00999

Atenolol: MedlinePlus Drug Information [Internet]. Medlineplus.gov. 2017 [cited 10 March 2017]. Available from:

https://medlineplus.gov/druginfo/meds/a684031.html

Losartan: MedlinePlus Drug Information [Internet]. Medlineplus.gov. 2017 [cited 8 March 2017]. Available from:

https://medlineplus.gov/druginfo/meds/a695008.html
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Information on this page was last updated on 19 Jul 2019

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