Itraconazole is a broad spectrum fungistatic drug. It inhibits 14 alpha demythelase and interferes with formation of ergosterol thus inhibiting fungal growth. Itraconazole is highly keratinophilic and lipophilic in nature. Its oral absorption is enhanced with food.
Indications: Itraconazole is FDA approved in the management if tinea unguium, esophageal and oropharyngeal candidiasis. It is also used in the management if tinea cruris, corporis, pityriasis versicolorand candidal intertrigo.
Dose and duration of treatment varies as per condition.
Contraindications:· Known hypersensitivity to Itraconazole·
Pregnancy Adverse effects: Skin rash, pruritus, rarely Steven Johnsonsyndrome might be noted with administration of itraconazole. Nausea, vomiting, diarrhoea may also be seen. Raised liver enzymes may be noted in some cases. Uncommon renal orneurological complications may be noted.
Itraconazole doses in common fungal infections:Tinea cruris: 100 mg bd for 2 to 4 weeks Tinea corporis: 100 mg bd for 2 to 4 weeks Tinea pedis: 200 mg bd for 2 weeks. Pulse dosing is used in cases ofonychomycosis as the drug accumulates in the nail and is shed off with the growth of the nail.