Pre-testicular causes of male infertility Pre-testicular causes signify those problems that obstruct efficient support of the testes also involves conditions of weak hormonal support in addition to weak overall health. The following are some of the pre-testicular factors:

  • Hypogonadotropic hypogonadism on account of numerous causes. If you are obese, then you have a greater chance of hypogonadotropic hypogonadism. It also brings about Leptin insensitivity in the hypothalamus, resulting in reduced Kiss1 expression, which, consequently, changes the discharge of gonadotropin-releasing hormone (GnRH).
  • Coeliac disease: Not taking sufficient care of coeliac disease (CD) or it is left undiagnosed. Coeliac males sometimes have reversible infertility. However, CD may found with a number of non-gastrointestinal signs or symptoms that may include just about any specific organ system, even in the lack of gastrointestinal signs or symptoms. Hence, the medical diagnosis could be overlooked, resulting in a chance of long-lasting problems. In males, CD may reduce semen quality as well as result in immature supplementary sex features, hypogonadism in addition to hyperprolactinaemia, which causes impotence and even lack of sex drive.
  • Drugs, alcoholic beverages.
  • Exhausting riding (cycling, horseback riding).
  • Prescription drugs, like those who influence spermatogenesis for instance chemotherapy, anabolic steroids, cimetidine, spironolactone; the ones that reduce FSH levels for instance phenytoin; the ones that reduce sperm motility like sulfasalazine and also nitrofurantoin.
  • Hereditary problems like a Robertsonian translocation
  • Smoking Cigarettes: Cautioning all the attendees at the Indira IVF clinic in Bangalore Dr ManjulaB.C. said that there are clear indications that the hazardous products in a cigarette harms the testicles and even destroys the sperm. Smoking tobacco enhances consumption of cadmium, simply because the tobacco plant assimilates the metal. Cadmium is chemically the same as zinc and might exchange zinc in the DNA polymerase, which has an important part in sperm generation. Zinc-substituted by cadmium in DNA polymerase could be quite harmful to the testes.