Primary myelofibrosis with JAK 2 mutatio

Question

Asked for Female, 67 Years

My farther aged 67 has been identified with prim myelofibrosis, he was advised to take Jakafi but that dropped his blood levels and didnt suit the body. he is now taking thalomid but has been detected with thyroid as well. he has not been eating ever since the tablets have begun due to which he has been hospitalized often for drips and is drowsy.

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Dr. Rakesh pinninti

Medical Oncologist 9 yrs exp Hyderabad

Hi There are very limited treatment options for Primary myelofibrosis apart from Jakafi.Even with Jakafi tolerance remains a major concern. Therapy responses to thalidomide and lenalidomide remain limited. In case JAKAFI is not tolerated there are options for dose modification, hope all options explored before stopping JAKAFI. At this present clinical status as per your description, we need to have a realistic approach to treatment decisions, with a goal to limit symptoms and discomfort ...sorry I could not contribute more.. Best wishes Dr Rakesh Pinninti

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Dr. Anita Malik Oncologist 18 yrs exp Delhi · Accepted Answer

Dr. Anita Malik

Oncologist 18 yrs exp Delhi

Follow your medical oncologist advise.