Calcification on the liver generally indicates calcium has formed in areas affected by past infection or injury, typically to protect the area from further damage. A calcified liver may be indicative of liver lesions or tumors, although liver calification is not commonly associated with a serious disorder or underlying condition. If, during a scan of the liver, the only irregularity seen is the presence of liver calcification, this is generally not a major cause for concern. Occasionally, medications may also cause calcification in the liver if the body reacts negatively to a drug.