Lifestyle changes may help ease indigestion. Your doctor may recommend: Avoiding foods that trigger indigestionEating five or six small meals a day instead of three large mealsReducing or eliminating the use of alcohol and caffeineAvoiding certain pain relievers, such as aspirin, ibuprofen and naproxenFinding alternatives for medications that trigger indigestionControlling stress and anxiety If your indigestion persists, medications may help. Over-the-counter antacids are generally the first choice. Other options include: Proton pump inhibitors (PPIs), which can reduce stomach acid. PPIs may be recommended if you experience heartburn along with indigestion.H-2-receptor antagonists (H2RAs), which also can reduce stomach acid.Prokinetics, which may be helpful if your stomach empties slowly.Antibiotics, if H. pylori bacteria are causing your indigestion.Antidepressants or anti-anxiety medications, which may ease the discomfort from indigestion by decreasing your sensation of pain.