Elevated level may b due to preterm or stress related . Repeat test after 2 wks .

The raised 17-OHP level may indicate Congenital Adrenal Hyperplasia (CAH), a metabolic disorder caused by a defect in steroid hormone production. However, in preterm babies, this hormone may be falsely elevated due to immature adrenal glands. As your baby has no other features of CAH, this may not indicate true disease.

May be due to preterm and stress due to respiratory distress .

Hello, I understand your concern An elevated 17-OHP can be a sign of a condition called Congenital Adrenal Hyperplasia (CAH). This is a genetic disorder affecting the adrenal glands, leading to problems in hormone production—specifically cortisol and sometimes aldosterone. The body compensates by producing excess androgen hormones. 62 nmol/L (2040 ng/dL) is elevated, but your baby is preterm (36 weeks), and false positives are common in preterm or stressed babies. Many babies with high levels do not have CAH, so we do not panic at this stage.

Mild increase in a late preterm can happen

Consult with Pediatrician physically for further evaluation and treatment

The baby is born preterm and had a stressful postnatal course. The high 17 OH progesterone can be secondary to it. Ideally the screening should have been done at least 48 hours after delivery. You need to test again now and then again at 2-3 weeks after birth. With a repeat test it is advisable to do a serum sodium, potassium and glucose. Preferably be in contact with a pediatric endocrinologist. The condition suggestive is of a deficiency of enzyme in the adrenal gland leading to a condition called congenital adrenal hyperplasia. Crucial steroid hormones are not formed leading to a condition where salt wasting occurs by 7-14 days after birth. Also these hormone imbalance also may cause an ambiguity in genitalia formation. For this reason too it is crucial that you follow with a pediatric endocrinologist. Labelling of proper sex at birth is of prime importance.

General advice would be to repeat the test in 7-10 days as it can also increase due to acute stress and in preterms.