Limb-girdle muscular dystrophy refers to a group of disorders that cause weakness and wasting of the muscles around the shoulders and hips. No specific treatment is available for any of the LGMD syndromes, though aggressive supportive care is essential to preserve muscle function, maximize functional ability, and prolong life expectancy. Orthopedic surgery may be needed to help correct or prevent contractures and scoliosis. Gene therapy using vectors based on the adeno-associated virus may become a viable treatment option in the future.